POLR2C and TAF15

Number of citations of the paper that reports this interaction (PMID 9488465)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		POLR2C	TAF15
Gene Name		polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytoplasm Microtubule Cytoskeleton	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Activity DNA Binding Protein Dimerization Activity	Nucleotide Binding DNA Binding Protein Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	Positive Regulation Of Transcription, DNA-templated
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ATF4 ATF7IP C11orf58 C14orf1 CCHCR1 EEF1A1 ITCH LRIF1 MYOG NEDD4 NFKBIA NUDT21 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2K POLR2L SMARCC2 STC2 TAF15 UBE2W	21 interactors: CACNA1A FUS HIST1H3A HIST2H2AC HIST2H4A HIST3H3 POLR2C POLR2E POLR2G PRMT1 PRMT8 SAFB SF1 TAF1 TAF12 TAF13 TAF5 TAF7 TBP YWHAG ZNF384
Entrez ID		5432	8148
HPRD ID		15945	09031
Ensembl ID		ENSG00000102978	ENSG00000172660
Uniprot IDs		P19387 Q6FGR6	Q86X94 Q92804
PDB IDs
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription Elongation From RNA Polymerase II Promoter Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process Viral Process Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome Stem Cell Maintenance RNA Splicing, Via Transesterification Reactions Regulation Of Viral Process RNA Splicing Transcription From RNA Polymerase II Promoter Stem Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression MRNA Processing Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Stem Cell Differentiation RNA Biosynthetic Process MRNA Metabolic Process Cellular Response To Stress Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter RNA Processing DNA Repair Regulation Of Type I Interferon Production NcRNA Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Termination Regulation Of RNA Metabolic Process Transcription From RNA Polymerase I Promoter Positive Regulation Of Type I Interferon Production DNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression	Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Gene Expression Viral Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Chromatin Organization Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Chromatin Silencing At RDNA Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Histone Modification MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression 7-methylguanosine MRNA Capping PiRNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Silencing 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Negative Regulation Of Megakaryocyte Differentiation Cellular Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Transcription, DNA-templated Chromatin Modification Cellular Macromolecule Biosynthetic Process RNA Splicing Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine MRNA Processing Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic
Tagcloud ?			amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping hnrnpa1 hnrnpa2b1 lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution tardbp tdp43 tremor
Tagcloud (Difference) ?			amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping hnrnpa1 hnrnpa2b1 lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution tardbp tdp43 tremor
Tagcloud (Intersection) ?