POLR2C and OTUD5

Number of citations of the paper that reports this interaction (PubMedID 30508113)
53

Data Source:
BioGRID (pull down)

		POLR2C	OTUD5
Description		RNA polymerase II subunit C	OTU deubiquitinase 5
Image
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol	Nucleus Cytosol
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II	Negative Regulation Of Cytokine Production Proteolysis Neural Crest Cell Differentiation Protein Deubiquitination Cell Differentiation Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Regulation Of Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Interacting Genes		32 interacting genes: ATF4 ATF7IP C11orf58 CCHCR1 EEF1A1 ERG28 ITCH LRIF1 MYOG NECAB2 NEDD4 NFKBIA NUDT21 OTUD5 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2J2 POLR2K POLR2L RPAP1 RSPH1 SMARCC2 STC2 TAF15 UBC UBE2W	12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5
Entrez ID		5432	55593
HPRD ID		15945	06488
Ensembl ID		ENSG00000102978	ENSG00000068308
Uniprot IDs		P19387 Q6FGR6	Q96G74
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	3PFY 3TMO 3TMP
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Nucleus RNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III TRNA Transcription Nucleobase-containing Compound Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Macromolecule Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase I 5'-3' RNA Polymerase Activity Protein Monoubiquitination Nucleolus Transcription By RNA Polymerase I Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotidyltransferase Activity Translation Initiation Factor Binding Negative Regulation Of Gene Expression Negative Regulation Of Potassium Ion Transport	RNA Polymerase II, Core Complex Ubiquitin Protein Ligase Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex DNA-templated Transcription 5'-3' RNA Polymerase Activity MRNA Transcription RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Protein Tag Activity Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus DNA Binding Nucleoplasm Macromolecule Biosynthetic Process RNA Binding MRNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Growth Cone Leading Edge Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription By RNA Polymerase II Interferon-mediated Signaling Pathway Promoter-specific Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Heterochromatin Boundary Formation Regulation Of DNA-templated Transcription Initiation Regulation Of Proteolysis Nucleotidyltransferase Activity Ribonucleoside Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Site Of Double-strand Break Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Circadian Rhythm Positive Regulation Of Thymocyte Apoptotic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?