POLR2C and RPAP1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (proximity labelling technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		POLR2C	RPAP1
Description		RNA polymerase II subunit C	RNA polymerase II associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol	DNA-directed RNA Polymerase Complex Nucleus
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	DNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II	Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS			A body shape index ( 34021172) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lung function (FEV1/FVC) ( 30175238 30804560) Medication use (drugs used in diabetes) ( 31015401) Peak expiratory flow ( 30804560) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ATF4 ATF7IP C11orf58 CCHCR1 EEF1A1 ERG28 ITCH LRIF1 MYOG NECAB2 NEDD4 NFKBIA NUDT21 OTUD5 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2J2 POLR2K POLR2L RPAP1 RSPH1 SMARCC2 STC2 TAF15 UBC UBE2W	7 interacting genes: GPN1 POLR2B POLR2C POLR2G POLR2L POT1 TERF2IP
Entrez ID		5432	26015
HPRD ID		15945	11522
Ensembl ID		ENSG00000102978	ENSG00000103932
Uniprot IDs		P19387 Q6FGR6	A8K2F9 Q9BWH6
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Nucleus RNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III TRNA Transcription Nucleobase-containing Compound Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Macromolecule Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase I 5'-3' RNA Polymerase Activity Protein Monoubiquitination Nucleolus Transcription By RNA Polymerase I Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotidyltransferase Activity Translation Initiation Factor Binding Negative Regulation Of Gene Expression Negative Regulation Of Potassium Ion Transport	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process DNA-directed RNA Polymerase Activity Macromolecule Biosynthetic Process Shelterin Complex Transcription By RNA Polymerase II Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping DNA-templated Transcription Nucleic Acid Metabolic Process Nucleoplasm Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere Regulation Of Telomere Maintenance Nucleus Ribonucleoside Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA Metabolic Process Negative Regulation Of DNA Metabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Organization Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding 5'-3' RNA Polymerase Activity Macromolecule Metabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere DEAD/H-box RNA Helicase Binding
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