POLE2 and SAP18

Number of citations of the paper that reports this interaction (PubMedID 11872158)
0

Data Source:
HPRD (two hybrid, in vitro)

		POLE2	SAP18
Description		DNA polymerase epsilon 2, accessory subunit	Sin3A associated protein 18
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	HDACs deacetylate histones NoRC negatively regulates rRNA expression mRNA Splicing - Major Pathway Potential therapeutics for SARS
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620	14 interacting genes: DEF6 ERBB3 HDAC1 IKZF1 INCA1 NOL12 NTAQ1 POLE2 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2
Entrez ID		5427	10284
HPRD ID		16007	04256
Ensembl ID		ENSG00000100479	ENSG00000150459
Uniprot IDs		P56282	O00422
PDB IDs		2V6Z 5VBN 7PFO 7PLO	2HDE
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization	Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Sin3-type Complex Transcription Corepressor Activity Nucleus Histone Deacetylase Complex Negative Regulation Of Stem Cell Population Maintenance Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Intermediate Filament Polymerization Ciliary Tip Ciliary Base Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Response To Methylglyoxal Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Programmed Cell Death ERBB3:ERBB2 Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Krueppel-associated Box Domain Binding Intermediate Filament Polymerization Or Depolymerization Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Response To Drug Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Stem Cell Population Maintenance
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