POLE2 and SAP18

Number of citations of the paper that reports this interaction (PMID 11872158)
8

Data Source:
HPRD (two hybrid, in vitro)

		POLE2	SAP18
Gene Name		polymerase (DNA directed), epsilon 2, accessory subunit	Sin3A-associated protein, 18kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle	Histone Deacetylase Complex Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity	Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression, Epigenetic Positive Regulation Of Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases	NoRC negatively regulates rRNA expression Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27	11 interactors: HDAC1 IKZF1 INCA1 NOL12 POLE2 RBM39 RNPS1 RPS3A SIN3A SUFU TADA3
Entrez ID		5427	10284
HPRD ID		16007	04256
Ensembl ID		ENSG00000100479	ENSG00000150459
Uniprot IDs		P56282	O00422
PDB IDs		2V6Z	2HDE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression	Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Chromatin Organization Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Nitrogen Compound Metabolic Process Histone Deacetylation Protein Deacetylation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Neutrophil Differentiation Response To Methylglyoxal Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Metabolic Process Regulation Of Histone Modification Positive Regulation Of Chromatin Silencing Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Tubulin Deacetylation Error-prone Translesion Synthesis Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Metabolic Process Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Tagcloud ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	agtpbp1 atic calb1 cct4 copa fabp7 h2afy hierarchical ids milieu neurofibrillary omnibus organized prdx3 rnf14 senile sfpq smarcb1 sorl1 ssbp1 stxbp3 syncrip syne2 tangles tmem59 treeview txnl4a ulk2 visualized
Tagcloud (Difference) ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	agtpbp1 atic calb1 cct4 copa fabp7 h2afy hierarchical ids milieu neurofibrillary omnibus organized prdx3 rnf14 senile sfpq smarcb1 sorl1 ssbp1 stxbp3 syncrip syne2 tangles tmem59 treeview txnl4a ulk2 visualized
Tagcloud (Intersection) ?