POLE2 and KAT5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (in vitro, two hybrid)

		POLE2	KAT5
Gene Name		polymerase (DNA directed), epsilon 2, accessory subunit	K(lysine) acetyltransferase 5
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle	Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Protein Complex Binding Metal Ion Binding Androgen Receptor Binding Repressing Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Chromatin Organization Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Viral Process Histone Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Acetylation
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146)
Protein-Protein Interactions		13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27	136 interactors: ALOX12 APBB1 APLP1 APLP2 APP AR ARIH2 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CREB1 CREBBP CRELD1 CSTF2 DLEU1 DUSP23 E2F1 EDNRA EFNA1 EP300 ESR1 ESR2 ETV6 FAM101B FAM135B FAM173A GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL1P1 GOLGA2 GSTO1 H2AFX H3F3B HABP4 HAP1 HDAC1 HDAC7 HIST1H3A HIST1H4A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMBOX1 HNRNPH3 IK IKZF3 IL9R KIAA1377 KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PHC2 PIH1D3 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RGL2 RRM1 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513
Entrez ID		5427	10524
HPRD ID		16007	03245
Ensembl ID		ENSG00000100479	ENSG00000172977
Uniprot IDs		P56282	Q92993
PDB IDs		2V6Z	2EKO 2OU2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression	Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Mitotic Cell Cycle Chromosome Organization Anatomical Structure Development Cellular Macromolecule Biosynthetic Process System Development Tissue Development Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cell Death Apoptotic Process Death Organelle Organization Programmed Cell Death Biosynthetic Process
Tagcloud ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?