POLE2 and POLE4

Number of citations of the paper that reports this interaction (PMID 10801849)
20

Data Source:
HPRD (in vitro)

		POLE2	POLE4
Gene Name		polymerase (DNA directed), epsilon 2, accessory subunit	polymerase (DNA-directed), epsilon 4, accessory subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity	DNA-directed DNA Polymerase Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Histone H3 Acetylation DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27	6 interactors: HSPA13 NFYB POLE POLE2 POLE3 UBE3A
Entrez ID		5427	56655
HPRD ID		16007	16238
Ensembl ID		ENSG00000100479
Uniprot IDs		P56282	Q9NR33
PDB IDs		2V6Z
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression	DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Replication Telomere Maintenance Via Telomere Lengthening DNA Replication Initiation Transcription-coupled Nucleotide-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication Sperm Entry G1/S Transition Of Mitotic Cell Cycle Chromosome Organization Error-prone Translesion Synthesis DNA Metabolic Process DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Base-excision Repair, Gap-filling Translesion Synthesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Synthesis Involved In DNA Repair Prostate Gland Growth Postreplication Repair Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Cellular Homeostasis Cellular Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Protein Autoubiquitination Mitotic Cell Cycle Histone H3 Acetylation Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Base-excision Repair Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Metabolic Process Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole3 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2
Tagcloud (Difference) ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole3 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2
Tagcloud (Intersection) ?