POLE2 and MAPRE1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		POLE2	MAPRE1
Gene Name		polymerase (DNA directed), epsilon 2, accessory subunit	microtubule-associated protein, RP/EB family, member 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Microtubule Cytoplasmic Microtubule Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity	Protein Binding Protein C-terminus Binding Poly(A) RNA Binding Microtubule Plus-end Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Cell Proliferation Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Cell Division Positive Regulation Of Microtubule Plus-end Binding
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27	40 interactors: ABCB1 APC APC2 APP AURKB BCL3 CDK5RAP2 CLASP1 CLASP2 CLIP1 COPS5 COPS8 CSN3 CYLD DCTN1 HSPA1A IKBKG KAT2B KAT5 KIF2C LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PDE4DIP PIK3R4 POLE2 PQBP1 PSMA1 SPDYE2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB
Entrez ID		5427	22919
HPRD ID		16007	04379
Ensembl ID		ENSG00000100479	ENSG00000101367
Uniprot IDs		P56282	B4DM33 Q15691
PDB IDs		2V6Z	1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3TQ7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression	Cell Cycle Process Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Microtubule-based Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Microtubule-based Process Response To Stimulus Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Chromosome Segregation Cullin Deneddylation Cellular Localization Regulation Of Wnt Signaling Pathway Establishment Or Maintenance Of Cell Polarity Response To Radiation Protein Deneddylation Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Component Assembly Spindle Checkpoint Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Microtubule Bundle Formation Response To Light Stimulus Cellular Protein Complex Assembly Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Difference) ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated	akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Intersection) ?