POLE2 and BAIAP2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLE2	BAIAP2L2
Description		DNA polymerase epsilon 2, accessory subunit	BAR/IMD domain containing adaptor protein 2 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen	Nucleoplasm Cytosol Plasma Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell-cell Contact Zone Anchoring Junction Clathrin Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Phospholipid Binding Lipid Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis	Plasma Membrane Organization Positive Regulation Of Actin Filament Polymerization Actin Filament Bundle Assembly Actin Crosslink Formation Membrane Organization
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	RHOF GTPase cycle
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)	Age-related hearing impairment ( 34108613) Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620	6 interacting genes: ABI3 FAM9B GABPB1 GLYCTK GRXCR1 POLE2
Entrez ID		5427	80115
HPRD ID		16007	07997
Ensembl ID		ENSG00000100479	ENSG00000128298
Uniprot IDs		P56282	Q6UXY1
PDB IDs		2V6Z 5VBN 7PFO 7PLO
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization	Glycerate Kinase Activity Vestibular Receptor Cell Development
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