DSC1 and UCHL5

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		DSC1	UCHL5
Gene Name		desmocollin 1	ubiquitin carboxyl-terminal hydrolase L5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytosol Ino80 Complex
	Molecular Function	Calcium Ion Binding	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Multiple sclerosis ( 23412934)	Cannabis dependence ( 21668797)
Protein-Protein Interactions		8 interactors: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1
Entrez ID		1823	51377
HPRD ID		00511	10293
Ensembl ID		ENSG00000134765	ENSG00000116750
Uniprot IDs		Q08554 Q9HB00	Q9Y5K5
PDB IDs			3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cell-cell Junction Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Cell Adhesion Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Intermediate Filament Organization Cell-cell Junction Assembly Regulation Of Muscle Contraction Regulation Of Heart Contraction Intermediate Filament Cytoskeleton Organization Cell Junction Assembly Intermediate Filament-based Process Regulation Of Membrane Potential Intermediate Filament Bundle Assembly Adherens Junction Organization Regulation Of Actin Filament-based Process Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Response To Progesterone Ventricular Cardiac Muscle Tissue Development Cellular Component Assembly Cardiac Muscle Tissue Morphogenesis Apoptotic Process Programmed Cell Death Muscle Tissue Morphogenesis Cell Death Death Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cytoskeleton Organization Establishment Of Protein Localization To Plasma Membrane Maternal Process Involved In Female Pregnancy Cardiac Ventricle Development Ventricular Compact Myocardium Morphogenesis Endothelial Cell-cell Adhesion Adherens Junction Maintenance Cardiac Chamber Development	Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Intersection) ?