DSC1

Description		desmocollin 1
Image
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Gap Junction Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Desmosome Maintenance Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Hair Follicle Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Establishment Of Skin Barrier Cell-cell Adhesion
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Multiple sclerosis ( 23412934)
Interacting Genes		10 interacting genes: DSG1 DSG2 DSP JUP NEIL3 PKP1 PKP2 PKP3 UCHL5 WEE2-AS1
Entrez ID		1823
HPRD ID		00511
Ensembl ID		ENSG00000134765
Uniprot IDs		Q08554 Q9HB00
PDB IDs		5IRY
Enriched GO Terms of Interacting Partners?		Desmosome Desmosome Organization Cornified Envelope Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell-cell Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Adhesion Heterotypic Cell-cell Adhesion Cell-cell Junction Assembly Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Alpha-catenin Binding Regulation Of Action Potential Homotypic Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cardiac Muscle Contraction Epithelial Cell-cell Adhesion Cell Junction Assembly Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intermediate Filament Regulation Of Muscle Contraction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Intermediate Filament Binding Regulation Of Muscle System Process Intermediate Filament Bundle Assembly Intermediate Filament Organization Regulation Of Blood Circulation Cell Adhesion Molecule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cadherin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Positive Regulation Of Protein Localization Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Protein Localization To Plasma Membrane
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