DSC1 and DSG2

Number of citations of the paper that reports this interaction (PubMedID 9214392)
43

Data Source:
HPRD (in vivo, in vitro)

		DSC1	DSG2
Description		desmocollin 1	desmoglein 2
Image
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Gap Junction Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane	Cornified Envelope Cytoplasm Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Desmosome Maintenance Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Hair Follicle Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Establishment Of Skin Barrier Cell-cell Adhesion	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Epithelial To Mesenchymal Transition Response To Progesterone Negative Regulation Of Apoptotic Process Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Mesenchymal To Epithelial Transition Stem Cell Proliferation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Sprouting Angiogenesis
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Multiple sclerosis ( 23412934)	Blood protein levels ( 30072576)
Interacting Genes		10 interacting genes: DSG1 DSG2 DSP JUP NEIL3 PKP1 PKP2 PKP3 UCHL5 WEE2-AS1	5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		1823	1829
HPRD ID		00511	00516
Ensembl ID		ENSG00000134765	ENSG00000046604
Uniprot IDs		Q08554 Q9HB00	A0AAQ5BGT2 Q14126
PDB IDs		5IRY	2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7A7D 7AGF 7AGG 8QJX 8QJY 8QK3
Enriched GO Terms of Interacting Partners?		Desmosome Desmosome Organization Cornified Envelope Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell-cell Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Adhesion Heterotypic Cell-cell Adhesion Cell-cell Junction Assembly Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Alpha-catenin Binding Regulation Of Action Potential Homotypic Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cardiac Muscle Contraction Epithelial Cell-cell Adhesion Cell Junction Assembly Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intermediate Filament Regulation Of Muscle Contraction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Intermediate Filament Binding Regulation Of Muscle System Process Intermediate Filament Bundle Assembly Intermediate Filament Organization Regulation Of Blood Circulation Cell Adhesion Molecule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cadherin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Positive Regulation Of Protein Localization Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Protein Localization To Plasma Membrane	Desmosome Cornified Envelope Desmosome Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Organization Adherens Junction Cell Junction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Adhesion Regulation Of Action Potential Homotypic Cell-cell Adhesion Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Cell Junction Organization Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Cell-cell Junction Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Assembly Protein Localization To Membrane Cadherin Binding Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Gamma-catenin-TCF7L2 Complex Localization Within Membrane Cell Adhesion Molecule Binding Maintenance Of Protein Localization At Cell Tip Regulation Of System Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Desmosome Maintenance Intermediate Filament Catenin-TCF7L2 Complex
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