DSC1 and DSG1

Number of citations of the paper that reports this interaction (PubMedID 9606214)
56

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DSC1	DSG1
Description		desmocollin 1	desmoglein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Gap Junction Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane	Cornified Envelope Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding Metal Ion Binding
	Biological Process	Desmosome Maintenance Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Hair Follicle Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Establishment Of Skin Barrier Cell-cell Adhesion	Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Progesterone Protein Stabilization Maternal Process Involved In Female Pregnancy Cell-cell Adhesion
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases			Striate palmoplantar keratoderma
GWAS		Multiple sclerosis ( 23412934)	Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)
Interacting Genes		10 interacting genes: DSG1 DSG2 DSP JUP NEIL3 PKP1 PKP2 PKP3 UCHL5 WEE2-AS1	8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3
Entrez ID		1823	1828
HPRD ID		00511	00515
Ensembl ID		ENSG00000134765	ENSG00000134760
Uniprot IDs		Q08554 Q9HB00	Q02413
PDB IDs		5IRY
Enriched GO Terms of Interacting Partners?		Desmosome Desmosome Organization Cornified Envelope Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell-cell Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Adhesion Heterotypic Cell-cell Adhesion Cell-cell Junction Assembly Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Alpha-catenin Binding Regulation Of Action Potential Homotypic Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cardiac Muscle Contraction Epithelial Cell-cell Adhesion Cell Junction Assembly Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intermediate Filament Regulation Of Muscle Contraction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Intermediate Filament Binding Regulation Of Muscle System Process Intermediate Filament Bundle Assembly Intermediate Filament Organization Regulation Of Blood Circulation Cell Adhesion Molecule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cadherin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Positive Regulation Of Protein Localization Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Protein Localization To Plasma Membrane	Desmosome Desmosome Organization Cornified Envelope Desmosome Assembly Cell-cell Junction Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Adherens Junction Alpha-catenin Binding Cell Junction Organization Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell Junction Assembly Cell-cell Junction Assembly Desmosome Maintenance Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell Adhesion Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Junction Cell-cell Junction Regulation Of Action Potential Homotypic Cell-cell Adhesion Intermediate Filament Binding Intermediate Filament Bundle Assembly Regulation Of Cardiac Muscle Contraction Cadherin Binding Regulation Of Striated Muscle Contraction Regulation Of Cell Adhesion Regulation Of Heart Rate Regulation Of Actin Filament-based Process Epithelial Cell-cell Adhesion Cell-cell Junction Maintenance Intermediate Filament Positive Regulation Of Cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Regulation Of Cell-substrate Adhesion Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Maintenance Ficolin-1-rich Granule Membrane Protein Localization To Membrane
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