DSC1 and PKP1

Number of citations of the paper that reports this interaction (PMID 14673151)
10

Data Source:
HPRD (two hybrid)

		DSC1	PKP1
Gene Name		desmocollin 1	plakophilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Intermediate Filament Plasma Membrane Desmosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding	Signal Transducer Activity Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Signal Transduction Multicellular Organismal Development Single Organismal Cell-cell Adhesion Intermediate Filament Bundle Assembly
Pathways			Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Multiple sclerosis ( 23412934)	Panic disorder ( 19165232)
Protein-Protein Interactions		8 interactors: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	8 interactors: DSC1 DSG1 DSP KRT14 KRT8 TNS2 UCHL5 VIM
Entrez ID		1823	5317
HPRD ID		00511	03579
Ensembl ID		ENSG00000134765	ENSG00000081277
Uniprot IDs		Q08554 Q9HB00	Q13835
PDB IDs			1XM9
Enriched GO Terms of Interacting Partners?		Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cell-cell Junction Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Cell Adhesion Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Intermediate Filament Organization Cell-cell Junction Assembly Regulation Of Muscle Contraction Regulation Of Heart Contraction Intermediate Filament Cytoskeleton Organization Cell Junction Assembly Intermediate Filament-based Process Regulation Of Membrane Potential Intermediate Filament Bundle Assembly Adherens Junction Organization Regulation Of Actin Filament-based Process Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Response To Progesterone Ventricular Cardiac Muscle Tissue Development Cellular Component Assembly Cardiac Muscle Tissue Morphogenesis Apoptotic Process Programmed Cell Death Muscle Tissue Morphogenesis Cell Death Death Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cytoskeleton Organization Establishment Of Protein Localization To Plasma Membrane Maternal Process Involved In Female Pregnancy Cardiac Ventricle Development Ventricular Compact Myocardium Morphogenesis Endothelial Cell-cell Adhesion Adherens Junction Maintenance Cardiac Chamber Development	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Anatomical Structure Development Apoptotic Process Programmed Cell Death Response To Stimulus Cell Death Developmental Process Death Cytoskeleton Organization System Development Epithelial Cell Differentiation Ventricular Compact Myocardium Morphogenesis Multicellular Organismal Development Organ Development Protein Localization To Adherens Junction Intermediate Filament Bundle Assembly Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Organization Response To Hydrostatic Pressure Bergmann Glial Cell Differentiation Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Cell Junction Signaling Central Nervous System Development Epidermis Development Cell Communication Hemidesmosome Assembly Desmosome Organization Epithelium Development Response To Muscle Activity Cell Adhesion Hepatocyte Apoptotic Process Lens Fiber Cell Development Ventricular Cardiac Muscle Cell Action Potential Forebrain Morphogenesis Astrocyte Development Regulation Of Heart Rate By Cardiac Conduction Lateral Ventricle Development
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Difference) ?		cadherins companion continuity desmocollin desmoglein desmosomal displaying dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Intersection) ?		desmoplakin desmosomes