DSC1 and PKP1

Number of citations of the paper that reports this interaction (PubMedID 14673151)
68

Data Source:
HPRD (two hybrid)

		DSC1	PKP1
Description		desmocollin 1	plakophilin 1
Image
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Gap Junction Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane Desmosome Perinuclear Region Of Cytoplasm Anchoring Junction Nuclear Stress Granule Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding
	Biological Process	Desmosome Maintenance Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Hair Follicle Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Establishment Of Skin Barrier Cell-cell Adhesion	Desmosome Assembly Desmosome Maintenance Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Transepithelial Water Transport Ameloblast Differentiation Intermediate Filament Bundle Assembly Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Protein Localization To Membrane
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases			Ectodermal dysplasia/skin fragility syndrome
GWAS		Multiple sclerosis ( 23412934)	Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		10 interacting genes: DSG1 DSG2 DSP JUP NEIL3 PKP1 PKP2 PKP3 UCHL5 WEE2-AS1	17 interacting genes: ARMC8 BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM
Entrez ID		1823	5317
HPRD ID		00511	03579
Ensembl ID		ENSG00000134765	ENSG00000081277
Uniprot IDs		Q08554 Q9HB00	Q13835
PDB IDs		5IRY	1XM9
Enriched GO Terms of Interacting Partners?		Desmosome Desmosome Organization Cornified Envelope Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell-cell Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Adhesion Heterotypic Cell-cell Adhesion Cell-cell Junction Assembly Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Alpha-catenin Binding Regulation Of Action Potential Homotypic Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cardiac Muscle Contraction Epithelial Cell-cell Adhesion Cell Junction Assembly Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intermediate Filament Regulation Of Muscle Contraction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Intermediate Filament Binding Regulation Of Muscle System Process Intermediate Filament Bundle Assembly Intermediate Filament Organization Regulation Of Blood Circulation Cell Adhesion Molecule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cadherin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Positive Regulation Of Protein Localization Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Protein Localization To Plasma Membrane	Cornified Envelope Desmosome Intermediate Filament Keratin Filament Binding Ficolin-1-rich Granule Membrane Intermediate Filament Organization Scaffold Protein Binding Desmosome Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Cytoskeleton Epidermis Development Anchoring Junction Cell-cell Junction Organization
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