ARID3A and XPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARID3A	XPA
Description		AT-rich interaction domain 3A	XPA, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Raft	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Identical Protein Binding	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio ( 20548946)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		21 interacting genes: ANKRD11 APP BTK DSP E2F1 E2F2 E2F4 KRT31 MAGEB2 MAGEB4 MORF4L1 MORF4L2 NOTCH2NLA PML REP15 SP100 TIMM8A TP53 TTC32 UBE2E3 XPA	51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		1820	7507
HPRD ID		10343	02045
Ensembl ID		ENSG00000116017	ENSG00000136936
Uniprot IDs		Q99856	P23025
PDB IDs		2KK0 4LJX	1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY
Enriched GO Terms of Interacting Partners?		Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Lens Fiber Cell Apoptotic Process Rb-E2F Complex Positive Regulation Of RNA Metabolic Process DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of RNA Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Type II Interferon-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Cell Cycle Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase PML Body Cellular Response To Stress Retinoic Acid Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Response To Stress DNA-binding Transcription Activator Activity Positive Regulation Of Macromolecule Metabolic Process Molecular Function Activator Activity Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription By RNA Polymerase II NuA4 Histone Acetyltransferase Complex Apoptotic Process Response To Light Stimulus RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of RNA Biosynthetic Process	DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition
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