ARID3A and E2F1

Number of citations of the paper that reports this interaction (PMID 9780002)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ARID3A	E2F1
Gene Name		AT rich interactive domain 3A (BRIGHT-like)	E2F transcription factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Membrane Raft	Nucleus Nucleoplasm Cytoplasm Rb-E2F Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Protein Homodimerization Activity	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Notch Signaling Pathway Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Anoikis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Cellular Response To Fatty Acid Cellular Response To Hypoxia Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Cellular Senescence Activation of BH3-only proteins Oncogene Induced Senescence Assembly of the pre-replicative complex Pre-NOTCH Transcription and Translation G2 Phase G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase M/G1 Transition Regulation of DNA replication G0 and Early G1 CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS		Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		12 interactors: APP BTK DSP E2F1 E2F2 E2F4 NOTCH2NL PML SP100 TP53 TTC32 UBE2E3	70 interactors: ARID3A ATAD2 ATM ATR BRCA1 BRD2 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 DDB2 E2F6 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NDNL2 NFKB1 NPDC1 NRIP1 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RNF144A SERTAD2 SETD7 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP VHL YWHAQ
Entrez ID		1820	1869
HPRD ID		10343	01806
Ensembl ID			ENSG00000101412
Uniprot IDs		Q99856	Q01094 Q9BSD8
PDB IDs		2KK0 4LJX	1H24 1O9K 2AZE
Enriched GO Terms of Interacting Partners?		Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Notch Signaling Pathway Lens Fiber Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Communication Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Response To Oxidative Stress Positive Regulation Of Histone Deacetylation Regulation Of Intracellular Transport Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Cycle DNA Damage Checkpoint Signal Transduction Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle Process Positive Regulation Of Protein Deacetylation Photoperiodism Entrainment Of Circadian Clock Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Response To Transforming Growth Factor Beta Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Senescence Intracellular Receptor Signaling Pathway	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Process Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process DNA Repair Cellular Response To Stress DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		carcinoembryonic colon colonic crc depth distant estimate favorable instability interactive kaplan meier member metastasis microarray microsatellite mucosa node predict predictor prognosis proportional rectal rich strong weak weakly	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Difference) ?		carcinoembryonic colon colonic crc depth distant estimate favorable instability interactive kaplan meier member metastasis microarray microsatellite mucosa node predict predictor prognosis proportional rectal rich strong weak weakly	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Intersection) ?