ARID3A and E2F2

Number of citations of the paper that reports this interaction (PMID 15017387)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ARID3A	E2F2
Gene Name		AT rich interactive domain 3A (BRIGHT-like)	E2F transcription factor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Membrane Raft	Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Protein Homodimerization Activity	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process
Pathways			DNA Replication Pre-Initiation Cellular Senescence G1 Phase M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Oxidative Stress Induced Senescence Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases
Drugs
Diseases
GWAS		Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		12 interactors: APP BTK DSP E2F1 E2F2 E2F4 NOTCH2NL PML SP100 TP53 TTC32 UBE2E3	17 interactors: ARID3A ATAD2 BCAR1 BRD2 CDK3 FHL2 GIT2 GNB5 RB1 RNF144A RYBP SETD8 SP1 SPIB TFDP1 TFDP2 YY1
Entrez ID		1820	1870
HPRD ID		10343	02692
Ensembl ID			ENSG00000007968
Uniprot IDs		Q99856	Q14209
PDB IDs		2KK0 4LJX	1N4M
Enriched GO Terms of Interacting Partners?		Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Notch Signaling Pathway Lens Fiber Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Communication Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Response To Oxidative Stress Positive Regulation Of Histone Deacetylation Regulation Of Intracellular Transport Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Cycle DNA Damage Checkpoint Signal Transduction Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle Process Positive Regulation Of Protein Deacetylation Photoperiodism Entrainment Of Circadian Clock Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Response To Transforming Growth Factor Beta Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Senescence Intracellular Receptor Signaling Pathway	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Androgen Receptor Signaling Pathway DNA-templated Transcription, Initiation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Modification Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Sequestering Of Nodal From Receptor Via Nodal Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		carcinoembryonic colon colonic crc depth distant estimate favorable instability interactive kaplan meier member metastasis microarray microsatellite mucosa node predict predictor prognosis proportional rectal rich strong weak weakly	accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually
Tagcloud (Difference) ?		carcinoembryonic colon colonic crc depth distant estimate favorable instability interactive kaplan meier member metastasis microarray microsatellite mucosa node predict predictor prognosis proportional rectal rich strong weak weakly	accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually
Tagcloud (Intersection) ?