ARID3A and E2F4

Number of citations of the paper that reports this interaction (PMID 15017387)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ARID3A	E2F4
Gene Name		AT rich interactive domain 3A (BRIGHT-like)	E2F transcription factor 4, p107/p130-binding
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Membrane Raft	Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Protein Homodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		12 interactors: APP BTK DSP E2F1 E2F2 E2F4 NOTCH2NL PML SP100 TP53 TTC32 UBE2E3	25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		1820	1874
HPRD ID		10343	02806
Ensembl ID			ENSG00000205250
Uniprot IDs		Q99856	Q16254
PDB IDs		2KK0 4LJX	1CF7
Enriched GO Terms of Interacting Partners?		Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Notch Signaling Pathway Lens Fiber Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Communication Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Response To Oxidative Stress Positive Regulation Of Histone Deacetylation Regulation Of Intracellular Transport Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Cycle DNA Damage Checkpoint Signal Transduction Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle Process Positive Regulation Of Protein Deacetylation Photoperiodism Entrainment Of Circadian Clock Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Response To Transforming Growth Factor Beta Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Senescence Intracellular Receptor Signaling Pathway	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication
Tagcloud ?		carcinoembryonic colon colonic crc depth distant estimate favorable instability interactive kaplan meier member metastasis microarray microsatellite mucosa node predict predictor prognosis proportional rectal rich strong weak weakly	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Difference) ?		carcinoembryonic colon colonic crc depth distant estimate favorable instability interactive kaplan meier member metastasis microarray microsatellite mucosa node predict predictor prognosis proportional rectal rich strong weak weakly	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Intersection) ?