ARID3A and E2F4

Number of citations of the paper that reports this interaction (PubMedID 15017387)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ARID3A	E2F4
Description		AT-rich interaction domain 3A	E2F transcription factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Raft	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis Blood Circulation Regulation Of Cell Size Animal Organ Morphogenesis Cell Projection Organization Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio ( 20548946)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		21 interacting genes: ANKRD11 APP BTK DSP E2F1 E2F2 E2F4 KRT31 MAGEB2 MAGEB4 MORF4L1 MORF4L2 NOTCH2NLA PML REP15 SP100 TIMM8A TP53 TTC32 UBE2E3 XPA	34 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RECQL RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRIM33 TRRAP USP2 XPO1
Entrez ID		1820	1874
HPRD ID		10343	02806
Ensembl ID		ENSG00000116017	ENSG00000205250
Uniprot IDs		Q99856	Q16254
PDB IDs		2KK0 4LJX	1CF7 5TUU
Enriched GO Terms of Interacting Partners?		Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Lens Fiber Cell Apoptotic Process Rb-E2F Complex Positive Regulation Of RNA Metabolic Process DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of RNA Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Type II Interferon-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Cell Cycle Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase PML Body Cellular Response To Stress Retinoic Acid Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Response To Stress DNA-binding Transcription Activator Activity Positive Regulation Of Macromolecule Metabolic Process Molecular Function Activator Activity Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription By RNA Polymerase II NuA4 Histone Acetyltransferase Complex Apoptotic Process Response To Light Stimulus RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of RNA Biosynthetic Process	Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Lipid Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromatin Positive Regulation Of Metabolic Process Co-SMAD Binding Chromatin Organization DNA Binding Regulation Of Cell Cycle Process IkappaB Kinase Activity Paraxial Mesoderm Morphogenesis Promoter-specific Chromatin Binding R-SMAD Binding Cell Differentiation BHLH Transcription Factor Binding Ubiquitin Protein Ligase Binding Mesoderm Morphogenesis Rb-E2F Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle
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