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DHX9 and EWSR1
Number of citations of the paper that reports this interaction (PMID
16740692
)
23
Data Source:
BioGRID
(pull down, affinity chromatography technology)
DHX9
EWSR1
Gene Name
DEAH (Asp-Glu-Ala-His) box helicase 9
EWS RNA-binding protein 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Membrane
Ribonucleoprotein Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Plasma Membrane
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
RNA Helicase Activity
ATP-dependent DNA Helicase Activity
ATP-dependent RNA Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Nucleotide Binding
RNA Binding
Protein Binding
Calmodulin Binding
Zinc Ion Binding
Identical Protein Binding
Poly(A) RNA Binding
Biological Process
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
RNA Processing
Circadian Rhythm
RNA Splicing
Gene Expression
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Cellular Response To Heat
Innate Immune Response
CRD-mediated MRNA Stabilization
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Pathways
mRNA Splicing
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Processing of Capped Intron-Containing Pre-mRNA
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
mRNA Splicing - Major Pathway
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
Protein-Protein Interactions
40 interactors:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
EIF2AK2
EWSR1
GEMIN2
GEMIN4
GTF2B
H2AFX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
MBD2
MGEA5
NXF1
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
159 interactors:
ACTL6A
AGT
ATN1
ATPAF2
ATXN3
BAD
BARD1
BLZF1
BNIP3L
BTK
C10orf12
C11orf16
C19orf57
CALM1
CCDC91
CD177
CDK12
CEACAM5
CETP
CFDP1
CHERP
CNST
CPSF6
CPSF7
CREBBP
CUEDC2
CXADR
DFFA
DHX9
DMRTB1
DNAJB3
DYNLL2
E2F8
ECD
ELAVL3
ELAVL4
ELK1
EP300
EPAS1
EPT1
ERCC5
FAM131C
FASN
FLI1
FUS
FXR2
GNPDA1
GPBP1L1
HBP1
HDAC3
HERPUD1
HIST1H2BN
HLTF
HMGA1
HMGN4
HNRNPUL1
HSPA2
IRF3
ITCH
ITGB5
JUN
KCNMB1
KEL
KHDRBS2
KRR1
KXD1
LILRA3
MAGEA11
MAPK1IP1L
MATK
MDFI
MNS1
MRPS18B
MSC
MTCP1
MTMR9
MVK
MYL6
MYO1F
MYOZ2
NBPF3
NDRG1
NDUFB1
NDUFV1
NINL
NLE1
NONO
NPPB
NSUN4
NTNG2
PCBP1
PDHX
PEF1
PGLS
PLSCR1
POLR2G
POLR3A
POU4F1
POU5F1
PRKCA
PRMT1
PRR13
PRRC2A
PRTFDC1
PRUNE2
PTK2B
RAB37
RAD23A
RALYL
RASL11B
RBPMS
RFX3
RHOXF2
RMND5B
RNF183
RPL31
RPS15A
SALL2
SCMH1
SEC24A
SEC24D
SERP2
SF1
SF3B4
SLC1A1
SLC22A24
SMAD1
SMAD4
SNRPC
SSBP2
SSBP3
SUPT4H1
SUV39H2
TAF1
TFG
TMSB4Y
TONSL
TPGS2
TRAF1
TRAF2
TRAF3
TRIM37
TRIM5
TRPV5
TSPAN3
TULP2
USP7
VPS72
WBP4
WDR37
WWP1
WWP2
YWHAG
YY1AP1
ZBTB1
ZDHHC3
ZNF165
ZNF184
ZNF383
Entrez ID
1660
2130
HPRD ID
04386
00592
Ensembl ID
ENSG00000135829
ENSG00000182944
Uniprot IDs
B3KU66
Q08211
Q01844
PDB IDs
3LLM
3VYX
3VYY
2CPE
Enriched GO Terms of Interacting Partners
?
MRNA Processing
RNA Splicing
MRNA Metabolic Process
RNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Spliceosomal SnRNP Assembly
Nitrogen Compound Metabolic Process
Regulation Of Viral Process
Regulation Of Viral Genome Replication
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Viral Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Gene Expression
Ribonucleoprotein Complex Assembly
Viral Process
Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecular Complex Assembly
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Chromosome Organization
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Viral Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Viral Genome Replication
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Cellular Metabolic Process
Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Response To Stress
Viral Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
RNA Processing
Negative Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Transcription, DNA-templated
MRNA Metabolic Process
MRNA Processing
Apoptotic Process
Regulation Of Intracellular Transport
Response To Virus
Programmed Cell Death
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cellular Localization
Regulation Of Cellular Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Transport
Immune System Process
Regulation Of Protein Localization
Cell Death
Defense Response
Death
Regulation Of Cell Death
Tagcloud
?
arranged
blue
cauda
cd99
cords
equina
focal
fusion
glomus
hybridization
immunophenotypic
indolent
infrequent
involving
ki
labeling
longstanding
mitoses
nerve
nests
neu
reverse
roots
rosette
round
smooth
spinal
transcriptase
wt1
Tagcloud (Difference)
?
arranged
blue
cauda
cd99
cords
equina
focal
fusion
glomus
hybridization
immunophenotypic
indolent
infrequent
involving
ki
labeling
longstanding
mitoses
nerve
nests
neu
reverse
roots
rosette
round
smooth
spinal
transcriptase
wt1
Tagcloud (Intersection)
?