XIRP1 and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 15454575)
0

Data Source:
HPRD (in vitro)

		XIRP1	ACTA1
Description		xin actin binding repeat containing 1	actin alpha 1, skeletal muscle
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Adherens Junction Focal Adhesion Cell Junction Desmosome Anchoring Junction	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Binding Actin Binding Protein Binding Actin Filament Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Actin Filament Organization Intracellular Protein Localization Myoblast Differentiation Involved In Skeletal Muscle Regeneration Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways			Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Social communication problems ( 24564958)
Interacting Genes		9 interacting genes: ACTA1 ENAH EVL FLNC NEB NEBL RNF10 SH3RF1 VASP	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		165904	58
HPRD ID		16727	00030
Ensembl ID		ENSG00000168334	ENSG00000143632
Uniprot IDs		Q702N8	P68133
PDB IDs			7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Binding Profilin Binding Lamellipodium Supramolecular Fiber Organization Cardiac Muscle Thin Filament Assembly Actin Polymerization Or Depolymerization Filopodium Stress Fiber SH3 Domain Binding Cytoskeleton Z Disc Focal Adhesion Regulation Of Actin Filament Length Actin Filament Binding Neuron Projection Guidance Axon Guidance Structural Constituent Of Muscle Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Sarcomere Actin Cytoskeleton Protein Homotetramerization Cytoskeletal Protein Binding Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Protein Tetramerization Muscle Cell Development Cytoplasm Regulation Of Actin Filament Polymerization Neuron Projection Development Somatic Muscle Development Mesenchyme Migration Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Thin Filament Assembly Cell Projection Negative Regulation Of Ruffle Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Schwann Cell Proliferation Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cytoskeleton Organization Striated Muscle Thin Filament Protein Homooligomerization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
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