RPS6KA6 and DNMT1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPS6KA6	DNMT1
Description		ribosomal protein S6 kinase A6	DNA methyltransferase 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Heterochromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin Mitochondrion Germ Cell Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding LncRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Cell Population Proliferation Epigenetic Programming Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Cellular Response To Amino Acid Stimulus Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Bisphenol A Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation STAT3 nuclear events downstream of ALK signaling Defective pyroptosis Nuclear events stimulated by ALK signaling in cancer
Drugs		Fostamatinib	Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS			Appendicular lean mass ( 33097823) Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	53 interacting genes: AKT1 BAZ2A BRAP CBX1 CEBPA CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ENSA EZH2 FBP1 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 LCOR MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SNHG6 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB UBC YWHAQ
Entrez ID		27330	1786
HPRD ID		02250	00532
Ensembl ID		ENSG00000072133	ENSG00000130816
Uniprot IDs		A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32	I6L9H2 P26358 Q59FP7
PDB IDs		6G76 6G77 6G78	3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A 6L1F 6X9I 6X9J 6X9K 7SFC 7SFD 7SFE 7SFF 7SFG 7XI9 7XIB 8V9U 8XQC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Chromatin Remodeling Nucleoplasm Heterochromatin Formation Transcription Corepressor Activity Chromatin Binding Epigenetic Regulation Of Gene Expression Nucleus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex Cellular Response To Stress Facultative Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription Corepressor Binding Enzyme Binding Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Rhythmic Process DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Epigenetic Programming Of Gene Expression DNA Binding Macromolecule Metabolic Process Response To Lipid Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Protein Tag Activity
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