RPS6KA6 and MPP1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPS6KA6	MPP1
Description		ribosomal protein S6 kinase A6	MAGUK p55 scaffold protein 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Cortical Cytoskeleton Stereocilium Centriolar Satellite Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	GMP Kinase Activity Signaling Receptor Binding Protein Binding
	Biological Process	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Signal Transduction GMP Metabolic Process GDP Metabolic Process Regulation Of Neutrophil Chemotaxis
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Sensory processing of sound by outer hair cells of the cochlea
Drugs		Fostamatinib
Diseases
GWAS			Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	46 interacting genes: ABCC4 ACER1 ACER2 AGPAT3 AMOTL2 AP2M1 APH1A ATP5F1C ATRAID DERL2 DGAT2L6 DLG4 DNPEP ERBIN FXR2 GADD45A GPRASP3 GSK3B GYPC HNRNPD INCA1 KLHL12 MAP3K20 MEOX2 NR1H2 OGT OPTN PAQR8 PRIMPOL RPRM RPS6KA1 RPS6KA6 SGSM2 SLC35E1 SMN1 SRSF10 STK3 STUB1 SYNGR3 TK1 TMEM239 TRIM55 TRIM63 USP21 UXT ZNF639
Entrez ID		27330	4354
HPRD ID		02250	02370
Ensembl ID		ENSG00000072133	ENSG00000130830
Uniprot IDs		A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32	B4E325 Q00013
PDB IDs		6G76 6G77 6G78	2EJY 2EV8 3NEY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development	Intracellular Signal Transduction TOR Signaling Ribosomal Protein S6 Kinase Activity N-acylsphingosine Amidohydrolase Activity
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