RPS6KA6 and SPTBN4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RPS6KA6	SPTBN4
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 6	spectrin, beta, non-erythrocytic 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol	Cytoplasm Cytosol Plasma Membrane Adherens Junction Spectrin Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Vesicular Exosome Cell Body Fiber
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding
	Biological Process	Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Synaptic Transmission Axon Guidance Central Nervous System Development Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Regulation Of Sodium Ion Transport Cytoskeletal Anchoring At Plasma Membrane Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane
Pathways		Axon guidance RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ADIRF APP C14orf1 CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 FBN3 FZD5 LMO4 MAPK3 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	12 interactors: ANK3 CDC37 CELSR3 CENPU DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6
Entrez ID		27330	57731
HPRD ID		02250	09372
Ensembl ID			ENSG00000160460
Uniprot IDs		Q9UK32	C9JY79 Q9H254
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Processing Regulation Of Early Endosome To Late Endosome Transport Cell Differentiation Biosynthetic Process Cardiac Ventricle Development Negative Regulation Of Cellular Metabolic Process Labyrinthine Layer Blood Vessel Development Sterol Metabolic Process Tissue Development Cardiac Chamber Development Neuron Maturation Regulation Of Cell Fate Commitment Apoptotic Process Cell Maturation Negative Regulation Of Protein Processing Regulation Of Cellular Process Tissue Morphogenesis Programmed Cell Death Placenta Blood Vessel Development	Cell Cycle Organelle Organization Axon Development Cytoskeleton Organization Locomotion Regulation Of Cellular Process Telencephalon Development Centrosome Cycle Nervous System Development Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Maintenance Of Protein Location In Plasma Membrane Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Neuron Projection Development Multicellular Organismal Development Cell Projection Morphogenesis Cellular Response To Mechanical Stimulus Generation Of Neurons Cell Part Morphogenesis Anatomical Structure Development Axon Guidance Neurogenesis Negative Regulation Of Phosphorylation Neuron Development Signal Transduction In Response To DNA Damage Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Delayed Rectifier Potassium Channel Activity Superior Temporal Gyrus Development Dense Core Granule Maturation Canonical Wnt Signaling Pathway Central Nervous System Development Signal Transduction Centrosome Organization Negative Regulation Of Binding Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Process Cell Morphogenesis Microtubule Organizing Center Organization Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Centriole-centriole Cohesion Developmental Process Protein Localization Neuron Differentiation Signaling Cell Projection Organization
Tagcloud ?		anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized
Tagcloud (Difference) ?		anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized
Tagcloud (Intersection) ?