RPS6KA6 and CLEC3B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPS6KA6	CLEC3B
Description		ribosomal protein S6 kinase A6	C-type lectin domain family 3 member B
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Granular Component Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding
	Biological Process	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Ossification Positive Regulation Of Plasminogen Activation Bone Mineralization
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Platelet degranulation
Drugs		Fostamatinib	Tenecteplase Lanoteplase Copper
Diseases
GWAS			Acne (severe) ( 24927181) Alzheimer's disease ( 33654092) Blood protein levels ( 30072576)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	12 interacting genes: ANXA7 APP CDKN1A GADD45A GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1
Entrez ID		27330	7123
HPRD ID		02250	01759
Ensembl ID		ENSG00000072133	ENSG00000163815
Uniprot IDs		A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32	E9PHK0 P05452
PDB IDs		6G76 6G77 6G78	1HTN 1RJH 1TN3 3L9J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development	Negative Regulation Of Multicellular Organismal Process Negative Regulation Of TORC2 Signaling Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Negative Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Modulation Of Chemical Synaptic Transmission Negative Regulation Of Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle TOR Signaling Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Glutamatergic Synapse Cellular Response To Growth Factor Stimulus Regulation Of TORC2 Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biosynthetic Process Apolipoprotein Binding Response To Growth Factor Regulation Of Fibrinolysis Regulation Of MAPK Cascade Fibrinolysis Negative Regulation Of Macromolecule Metabolic Process Developmental Growth Signaling Receptor Binding Central Nervous System Development Regulation Of Reactive Oxygen Species Metabolic Process Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Serine-type Endopeptidase Activity Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition Positive Regulation Of Coagulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?