SIK1 and RNF2

Number of citations of the paper that reports this interaction (PubMedID 27911266)
24

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SIK1	RNF2
Description		salt inducible kinase 1	ring finger protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Protein Kinase Binding Histone Deacetylase Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Anoikis Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs		Dabrafenib Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27618452 27841878 28739976)	Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		13 interacting genes: CRTC2 HDAC5 ITCH MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ	65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1
Entrez ID		150094	6045
HPRD ID		09301	07028
Ensembl ID		ENSG00000142178	ENSG00000121481
Uniprot IDs		P57059	Q99496
PDB IDs			2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Golgi Localization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Cellular Response To Interleukin-4 Regulation Of TOR Signaling Response To Interleukin-4 Regulation Of Intracellular Signal Transduction Organelle Localization Regulation Of Metabolic Process Macromolecule Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Response To Stress Cellular Response To Heat Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Regulation Of Developmental Process TORC1 Signaling Positive Regulation Of Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Axonogenesis DSIF Complex Synaptic Target Recognition Nicotinamide-nucleotide Adenylyltransferase Activity Enzyme Binding Regulation Of Cell Growth Single-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Response To Heat Regulation Of Calcium-mediated Signaling Regulation Of Gene Expression Protein Metabolic Process Mitotic DNA Replication Initiation Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Protein Phosphorylation Negative Regulation Of Intracellular Signal Transduction	Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II
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