SIK1 and CRTC2

Number of citations of the paper that reports this interaction (PubMedID 16306228)
0

Data Source:
HPRD (in vitro, in vivo)

		SIK1	CRTC2
Description		salt inducible kinase 1	CREB regulated transcription coactivator 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Protein Kinase Binding Histone Deacetylase Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Anoikis Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cellular Response To CAMP
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Dabrafenib Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27618452 27841878 28739976)	Age at first birth ( 27798627 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: CRTC2 HDAC5 ITCH MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ	15 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 NEDD4 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ
Entrez ID		150094	200186
HPRD ID		09301	12347
Ensembl ID		ENSG00000142178	ENSG00000160741
Uniprot IDs		P57059	Q53ET0
PDB IDs			4HTM
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Golgi Localization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Cellular Response To Interleukin-4 Regulation Of TOR Signaling Response To Interleukin-4 Regulation Of Intracellular Signal Transduction Organelle Localization Regulation Of Metabolic Process Macromolecule Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Response To Stress Cellular Response To Heat Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Regulation Of Developmental Process TORC1 Signaling Positive Regulation Of Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Axonogenesis DSIF Complex Synaptic Target Recognition Nicotinamide-nucleotide Adenylyltransferase Activity Enzyme Binding Regulation Of Cell Growth Single-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Response To Heat Regulation Of Calcium-mediated Signaling Regulation Of Gene Expression Protein Metabolic Process Mitotic DNA Replication Initiation Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Protein Phosphorylation Negative Regulation Of Intracellular Signal Transduction	Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Protein Modification Process Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Localization Regulation Of TORC1 Signaling Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of TOR Signaling Protein Sequestering Activity Phosphorylation Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Cellular Response To Glucose Starvation Protein Localization To Lysosome Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TORC1 Signaling Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Immune Response To Tumor Cell Protein Localization To Vacuole Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Immune Response To Tumor Cell Protein Catabolic Process Negative Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Nucleocytoplasmic Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?