SIK1 and RPL3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SIK1	RPL3
Gene Name		salt-inducible kinase 1	ribosomal protein L3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Cellular Response To Interleukin-4
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CRTC2 HDAC5 NMNAT1 PRKACA RPL3 STK11 SUPT5H VAPA YWHAZ	4 interactors: NDRG1 NUMB SIK1 STXBP3
Entrez ID		150094	6122
HPRD ID		09301	16042
Ensembl ID		ENSG00000142178	ENSG00000100316
Uniprot IDs		P57059	B3KS36 P39023 Q96QL0
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		Golgi Localization Intrinsic Apoptotic Signaling Pathway Chromatin Modification Glucose Homeostasis Cell Activation Histone H3-K9 Modification Chromatin Organization Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Membrane Organization Response To Glucagon Gluconeogenesis Cellular Response To Peptide Apoptotic Signaling Pathway Hexose Biosynthetic Process Organelle Organization Positive Regulation Of Viral Process Histone Modification Biosynthetic Process Chromosome Organization Positive Regulation Of Dense Core Granule Biogenesis TCR Signalosome Assembly Cell Death Death Cellular Metabolic Process Gene Expression Response To Peptide Hormone Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Leukocyte Activation Response To Peptide Regulation Of Endothelial Cell Migration Protein Localization To Organelle Histone H3-K9 Acetylation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T6 Phosphorylation Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation Of Signal Transduction Viral Process Protein Localization To Endoplasmic Reticulum Regulation Of Osteoblast Differentiation Cellular Response To Hormone Stimulus Response To Organic Substance Energy Reserve Metabolic Process Spermatid Development Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process	Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Polarized Epithelial Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of Anoikis Neuroblast Division In Subventricular Zone System Development Positive Regulation Of Spindle Checkpoint Neutrophil Degranulation Protein To Membrane Docking Neutrophil Activation Involved In Immune Response Positive Regulation Of Cell Cycle Checkpoint Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Gluconeogenesis Forebrain Neuroblast Division Leukocyte Activation Developmental Process Regulation Of Anoikis Regulation Of Triglyceride Biosynthetic Process Peripheral Nervous System Myelin Maintenance Signaling Negative Regulation Of Calcium Ion-dependent Exocytosis Nervous System Development Negative Regulation Of Protein Localization To Plasma Membrane Neutrophil Mediated Immunity Cell Communication Lateral Ventricle Development Neutrophil Activation Entrainment Of Circadian Clock By Photoperiod Regulation Of Spindle Checkpoint Somatic Stem Cell Division Photoperiodism Entrainment Of Circadian Clock Cell Activation Myelin Maintenance Negative Regulation Of Notch Signaling Pathway Mast Cell Activation Regulation Of Triglyceride Metabolic Process Brain Development Regulation Of Cell Cycle Checkpoint Negative Regulation Of Exocytosis Head Development Platelet Aggregation Stem Cell Division Leukocyte Degranulation Insulin Secretion Ventricular System Development Myelination In Peripheral Nervous System Organ Development Membrane Organization
Tagcloud ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x	4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas pgk1 polysome pyk1 raising rp29 saccharomyces starvation stationary thi4 translatabilities translated translational
Tagcloud (Difference) ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x	4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas pgk1 polysome pyk1 raising rp29 saccharomyces starvation stationary thi4 translatabilities translated translational
Tagcloud (Intersection) ?