SIK1

Description		salt inducible kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Protein Kinase Binding Histone Deacetylase Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Anoikis Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs		Dabrafenib Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		13 interacting genes: CRTC2 HDAC5 ITCH MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ
Entrez ID		150094
HPRD ID		09301
Ensembl ID		ENSG00000142178
Uniprot IDs		P57059
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Golgi Localization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Cellular Response To Interleukin-4 Regulation Of TOR Signaling Response To Interleukin-4 Regulation Of Intracellular Signal Transduction Organelle Localization Regulation Of Metabolic Process Macromolecule Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Response To Stress Cellular Response To Heat Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Regulation Of Developmental Process TORC1 Signaling Positive Regulation Of Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Axonogenesis DSIF Complex Synaptic Target Recognition Nicotinamide-nucleotide Adenylyltransferase Activity Enzyme Binding Regulation Of Cell Growth Single-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Response To Heat Regulation Of Calcium-mediated Signaling Regulation Of Gene Expression Protein Metabolic Process Mitotic DNA Replication Initiation Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Protein Phosphorylation Negative Regulation Of Intracellular Signal Transduction
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