SIK1 and NMNAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SIK1	NMNAT1
Description		salt inducible kinase 1	nicotinamide nucleotide adenylyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Protein Kinase Binding Histone Deacetylase Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Nicotinamide-nucleotide Adenylyltransferase Activity Catalytic Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Anoikis Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Purine Nucleotide Metabolic Process Nicotinamide Metabolic Process Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Response To Wounding Pyridine Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development ATP Generation From Poly-ADP-D-ribose
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Nicotinate metabolism
Drugs		Dabrafenib Fostamatinib	Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27618452 27841878 28739976)	Resting heart rate ( 27798624)
Interacting Genes		13 interacting genes: CRTC2 HDAC5 ITCH MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ	19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		150094	64802
HPRD ID		09301	16369
Ensembl ID		ENSG00000142178	ENSG00000173614
Uniprot IDs		P57059	B1AN62 Q9HAN9
PDB IDs			1GZU 1KKU 1KQN 1KQO 1KR2 8QE8
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Golgi Localization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Cellular Response To Interleukin-4 Regulation Of TOR Signaling Response To Interleukin-4 Regulation Of Intracellular Signal Transduction Organelle Localization Regulation Of Metabolic Process Macromolecule Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Response To Stress Cellular Response To Heat Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Regulation Of Developmental Process TORC1 Signaling Positive Regulation Of Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Axonogenesis DSIF Complex Synaptic Target Recognition Nicotinamide-nucleotide Adenylyltransferase Activity Enzyme Binding Regulation Of Cell Growth Single-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Response To Heat Regulation Of Calcium-mediated Signaling Regulation Of Gene Expression Protein Metabolic Process Mitotic DNA Replication Initiation Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Protein Phosphorylation Negative Regulation Of Intracellular Signal Transduction	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Localization To Nucleus Intracellular Transport Of Virus Host Cell Protein Import Into Nucleus Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Triglyceride Biosynthetic Process Cellular Localization Intracellular Protein Transport Regulation Of Amyloid Precursor Protein Catabolic Process Intracellular Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Negative Regulation Of Triglyceride Metabolic Process Establishment Of Localization In Cell Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Life Cycle Establishment Of Protein Localization Regulation Of Anoikis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Receptor Internalization Intracellular Protein Localization Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Cellular Response To Nerve Growth Factor Stimulus Protein Transport Viral Process Regulation Of Muscle Cell Differentiation
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