SIK1 and NMNAT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SIK1	NMNAT1
Gene Name		salt-inducible kinase 1	nicotinamide nucleotide adenylyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process NAD Biosynthetic Process NAD Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs			Nicotinamide-Adenine-Dinucleotide Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CRTC2 HDAC5 NMNAT1 PRKACA RPL3 STK11 SUPT5H VAPA YWHAZ	10 interactors: APP CCNC FLOT2 KPNA2 MSX1 NEK3 NTRK2 SIK1 SIRT1 TDO2
Entrez ID		150094	64802
HPRD ID		09301	16369
Ensembl ID		ENSG00000142178	ENSG00000173614
Uniprot IDs		P57059	B1AN62 Q9HAN9
PDB IDs			1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?		Golgi Localization Intrinsic Apoptotic Signaling Pathway Chromatin Modification Glucose Homeostasis Cell Activation Histone H3-K9 Modification Chromatin Organization Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Membrane Organization Response To Glucagon Gluconeogenesis Cellular Response To Peptide Apoptotic Signaling Pathway Hexose Biosynthetic Process Organelle Organization Positive Regulation Of Viral Process Histone Modification Biosynthetic Process Chromosome Organization Positive Regulation Of Dense Core Granule Biogenesis TCR Signalosome Assembly Cell Death Death Cellular Metabolic Process Gene Expression Response To Peptide Hormone Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Leukocyte Activation Response To Peptide Regulation Of Endothelial Cell Migration Protein Localization To Organelle Histone H3-K9 Acetylation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T6 Phosphorylation Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation Of Signal Transduction Viral Process Protein Localization To Endoplasmic Reticulum Regulation Of Osteoblast Differentiation Cellular Response To Hormone Stimulus Response To Organic Substance Energy Reserve Metabolic Process Spermatid Development Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process	Regulation Of Cell Cycle Regulation Of Protein Stability Response To Radiation Regulation Of Anoikis Posttranscriptional Regulation Of Gene Expression Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cellular Ketone Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Neuromuscular Junction Development Rhythmic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Cardiovascular System Development Positive Regulation Of Response To DNA Damage Stimulus Establishment Of Chromatin Silencing Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Regulation Of Protein Phosphorylation Forebrain Development Response To Abiotic Stimulus Feeding Behavior Regulation Of Striated Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Triglyceride Biosynthetic Process Synaptic Growth At Neuromuscular Junction Behavioral Response To Starvation Tryptophan Catabolic Process To Acetyl-CoA Regulation Of Glucose Metabolic Process Regulation Of Gene Expression Muscle Structure Development Regulation Of Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase B Signaling Negative Regulation Of CREB Transcription Factor Activity Maintenance Of Chromatin Silencing Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Chromatin Silencing Collateral Sprouting In Absence Of Injury
Tagcloud ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x	adenylyltransferase amaurosis atrophy autosomal caucasian cone crd dystrophies dystrophy e257k encompassed harbors heterozygous inherited insignificant lca leber macular modifier nicotinamide persons pigmentosa recessive retinitis rod rp sanger truncating variants
Tagcloud (Difference) ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs stimulant taf1 ube2d2 uqcrc2 usp27x	adenylyltransferase amaurosis atrophy autosomal caucasian cone crd dystrophies dystrophy e257k encompassed harbors heterozygous inherited insignificant lca leber macular modifier nicotinamide persons pigmentosa recessive retinitis rod rp sanger truncating variants
Tagcloud (Intersection) ?