PCGF1 and CBX7

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		PCGF1	CBX7
Description		polycomb group ring finger 1	chromobox 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Chromatin Nucleus Nucleoplasm Cytosol PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization
Pathways
Drugs
Diseases
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Lymphocyte count ( 27863252 32888494) Menarche (age at onset) ( 25231870) Multiple myeloma ( 23955597 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		10 interacting genes: CALCOCO2 CBX7 FCHO1 H2AC4 MUC7 RNF125 RNF2 TRIM55 UBE2D3 UBE2U	12 interacting genes: B3GNT5 H3-3A H3-4 H3C1 H3C14 PCGF1 PCGF5 PCGF6 RING1 RNF2 SUV39H2 ZRANB1
Entrez ID		84759	23492
HPRD ID		11404	12234
Ensembl ID		ENSG00000115289	ENSG00000100307
Uniprot IDs		Q9BSM1	B0QYP2 O95931 Q4PNR6
PDB IDs		4HPL 4HPM 5JH5 8HCU	2K1B 2L12 2L1B 3GS2 4MN3 5EPJ 6V2R 8SII
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity PRC1 Complex Protein Modification By Small Protein Conjugation Post-translational Protein Modification PcG Protein Complex Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Granzyme B Production	Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex Structural Constituent Of Chromatin Nucleoplasm Nucleosome Assembly Epigenetic Regulation Of Gene Expression Nucleosome Nucleosome Organization Histone H2AK119 Ubiquitin Ligase Activity Chromosome Protein-DNA Complex Assembly Sex Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Activity Regulation Of Gene Expression Gene Expression Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Chromosome Condensation Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Spermatogonial Cell Division Protein K29-linked Deubiquitination Histone H3K9 Trimethyltransferase Activity X Chromosome Pericentric Heterochromatin Formation Telomere Organization Protein K33-linked Deubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Centromere Complex Assembly Heterochromatin Formation
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