PCGF1 and RNF125

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		PCGF1	RNF125
Gene Name		polycomb group ring finger 1	ring finger protein 125, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H2A Monoubiquitination	Protein Ubiquitination Negative Regulation Of Type I Interferon Production Innate Immune Response
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BCORL1 CALCOCO2 CBX6 CBX7 CBX8 PCGF5 RING1 RNF125 RNF2 TRIM55 UBE2U	17 interactors: CHFR PCGF1 PML TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2
Entrez ID		84759	54941
HPRD ID		11404	11500
Ensembl ID			ENSG00000101695
Uniprot IDs		Q9BSM1	Q96EQ8
PDB IDs		4HPL 4HPM
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Chromatin Modification Chromatin Organization Chromosome Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Monoubiquitination Histone H2A Ubiquitination Transcription, DNA-templated Histone Modification RNA Biosynthetic Process Histone Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Protein Monoubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Histone H2A-K119 Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Sebaceous Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Cellular Protein Modification Process Pattern Specification Process Negative Regulation Of Type I Interferon Production Gastrulation With Mouth Forming Second Regulation Of Metabolic Process Anterior/posterior Axis Specification Cellular Protein Metabolic Process	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein K48-linked Ubiquitination Proteolysis Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 4 Signaling Pathway Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To DNA Damage Stimulus Cellular Response To Oxygen Levels Response To Hypoxia Response To Stress Protein K63-linked Ubiquitination Cellular Metabolic Process Histone Ubiquitination Positive Regulation Of Protein Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Protein Monoubiquitination
Tagcloud ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	75a ag aims basel blotting c72 degradation e3 exogenous gst immunoprecipitation interacted interfere interference ip karger ligase mdm2 negatively p53 physically proteasome pull repressed thought transactivation ubiquitin ubiquitinated ubiquitination
Tagcloud (Difference) ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	75a ag aims basel blotting c72 degradation e3 exogenous gst immunoprecipitation interacted interfere interference ip karger ligase mdm2 negatively p53 physically proteasome pull repressed thought transactivation ubiquitin ubiquitinated ubiquitination
Tagcloud (Intersection) ?