PCGF1 and RNF125

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		PCGF1	RNF125
Description		polycomb group ring finger 1	ring finger protein 125
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Golgi Membrane Cytoplasm Golgi Apparatus Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription	Protein Polyubiquitination Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways			Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Interacting Genes		10 interacting genes: CALCOCO2 CBX7 FCHO1 H2AC4 MUC7 RNF125 RNF2 TRIM55 UBE2D3 UBE2U	26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MAVS MYOZ3 PCGF1 PML PNMA6A RIGI SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2U UBE2W USP2 ZNF414
Entrez ID		84759	54941
HPRD ID		11404	11500
Ensembl ID		ENSG00000115289	ENSG00000101695
Uniprot IDs		Q9BSM1	Q96EQ8
PDB IDs		4HPL 4HPM 5JH5 8HCU	5DKA 8GBQ 8GCB
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity PRC1 Complex Protein Modification By Small Protein Conjugation Post-translational Protein Modification PcG Protein Complex Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Granzyme B Production	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Entrainment Of Circadian Clock By Photoperiod Antiviral Innate Immune Response Catabolic Process Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Defense Response To Virus By Host Nucleotide Binding ATP Binding Transferase Activity Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of RNA Biosynthetic Process Defense Response To Virus Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Macromolecule Metabolic Process MRNA Transcription TORC1 Signaling Regulation Of Defense Response To Virus DNA Damage Response Regulation Of RNA Metabolic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Response To Cytokine Stimulus Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Catabolic Process
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