RNF213

Description		ring finger protein 213
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Lipid Droplet Cytosol Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Protein Ubiquitination Regulation Of Lipid Metabolic Process Defense Response To Bacterium Protein Autoubiquitination Protein K63-linked Ubiquitination Xenophagy Lipid Ubiquitination Lipid Droplet Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Suppression of apoptosis Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 33020668) Hypertension ( 32709000) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Migraine ( 27182965 27322543) Moyamoya disease ( 21048783 29273593)
Novel Interacting Genes		1 novel interacting genes: RPTOR
Interacting Genes		17 interacting genes: GLUD1 GOLGA2 KRT40 MTDH PLAC9 REL SUMO2 TRIM23 TRIM27 TRIP6 UBC UBE2D2 UBE2D3 UBE2K UBE2L3 UBE2U UBXN11
Entrez ID		57674
HPRD ID		10716
Ensembl ID		ENSG00000173821
Uniprot IDs		A0A0A0MTC1 A0A0A0MTR7 Q63HN8
PDB IDs		8S24
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Macromolecule Catabolic Process Protein Tag Activity Proteolysis Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity SUMO Transferase Activity Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Catabolic Process Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Autophagy Macromolecule Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Sumoylation Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity ATP Binding Protein Autoubiquitination Transcription Coactivator Activity
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