RNF213 and GLUD1

Number of citations of the paper that reports this interaction (PubMedID 34269483)
73

Data Source:
BioGRID (enzymatic study)

		RNF213	GLUD1
Description		ring finger protein 213	glutamate dehydrogenase 1
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Lipid Droplet Cytosol Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Catalytic Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity ADP Binding NAD+ Binding L-leucine Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Protein Ubiquitination Regulation Of Lipid Metabolic Process Defense Response To Bacterium Protein Autoubiquitination Protein K63-linked Ubiquitination Xenophagy Lipid Ubiquitination Lipid Droplet Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway	Amino Acid Metabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process
Pathways		Suppression of apoptosis Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation	Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation
Drugs			Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 33020668) Hypertension ( 32709000) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Migraine ( 27182965 27322543) Moyamoya disease ( 21048783 29273593)	Renal underexcretion gout ( 32238385)
Interacting Genes		17 interacting genes: GLUD1 GOLGA2 KRT40 MTDH PLAC9 REL SUMO2 TRIM23 TRIM27 TRIP6 UBC UBE2D2 UBE2D3 UBE2K UBE2L3 UBE2U UBXN11	16 interacting genes: ASGR2 CRP CUL3 DYNLL1 GOT2 HPX HSD17B10 KLHL22 LSM1 NR4A1 OGT ORM1 RNF213 STAT5A TIAM1 VTN
Entrez ID		57674	2746
HPRD ID		10716	11748
Ensembl ID		ENSG00000173821	ENSG00000148672
Uniprot IDs		A0A0A0MTC1 A0A0A0MTR7 Q63HN8	E9KL48 P00367
PDB IDs		8S24	1L1F 1NR1 6DQG 7UZM 8KGY 8SK8 8W4J
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Macromolecule Catabolic Process Protein Tag Activity Proteolysis Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity SUMO Transferase Activity Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Catabolic Process Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Autophagy Macromolecule Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Sumoylation Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity ATP Binding Protein Autoubiquitination Transcription Coactivator Activity	Positive Regulation Of Gene Expression Non-canonical Inflammasome Complex Assembly Polar Microtubule Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of TORC1 Signaling Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Inflammatory Response Cell-matrix Adhesion Cellular Component Assembly Transcription By RNA Polymerase II Defense Response Response To Peptide Hormone Blood Microparticle Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Mediated Immunity Mitotic Spindle Positive Regulation Of Biosynthetic Process Asialoglycoprotein Receptor Activity Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Acute-phase Response Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Mononuclear Cell Proliferation Acute Inflammatory Response DNA-templated Transcription Mesenchymal Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Cellular Response To Oxygen-containing Compound Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Gastrulation Positive Regulation Of Cell Population Proliferation Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Glial Cell Fate Determination Oligodendrocyte Differentiation
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