TRIM2 and SIRPA

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		TRIM2	SIRPA
Gene Name		tripartite motif containing 2	signal-regulatory protein alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	SH3 Domain Binding
	Biological Process	Protein Ubiquitination Regulation Of Neuron Apoptotic Process	Cell Adhesion Blood Coagulation Leukocyte Migration
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Multiple sclerosis ( 21654844)	Aortic root size ( 21223598) Mean platelet volume ( 22139419 19820697)
Protein-Protein Interactions		23 interactors: BCL2L11 CIB3 DTNBP1 GJB5 MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W	12 interactors: CCDC57 CD47 IL1RAP JAK2 KRT15 KRT31 KRT40 NOL3 PTPN11 PTPN6 TRIM2 TRIM27
Entrez ID		23321	140885
HPRD ID		10279	03912
Ensembl ID		ENSG00000109654	ENSG00000198053
Uniprot IDs		Q9C040	P78324
PDB IDs			2JJS 2JJT 2UV3 2WNG
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Stress Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Activation Of Innate Immune Response Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Innate Immune Response Protein K11-linked Deubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Cellular Response To DNA Damage Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein K48-linked Deubiquitination Negative Regulation Of Protein Ubiquitination Protein K63-linked Deubiquitination Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Cellular Response To Oxygen Levels Cellular Response To Organic Substance Pigmentation Cellular Metabolic Process Response To Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Abortive Mitotic Cell Cycle Response To Wounding Positive Regulation Of Cell Activation Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Megakaryocyte Development Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Cell Activation Platelet Formation Platelet Morphogenesis Megakaryocyte Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Negative Regulation Of Cell Adhesion Wound Healing Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Immune System Process Immune Response Regulation Of Immune System Process Leukocyte Migration Negative Regulation Of Adaptive Immune Response Response To Stress Defense Response Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Growth Hormone Myeloid Cell Differentiation Regulation Of Type I Interferon-mediated Signaling Pathway Response To Cytokine Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Regulation Of Kinase Activity JAK-STAT Cascade
Tagcloud ?		acc adenoid aetiology bbc col9a3 constitutes driver drivers foxa1 gpm6b insidious lacks massive mel metastasise metastasises mia myoepithelial neuroblastomaand oestrogen recur ropn1 ropn1b segregated shares signatures silico sox10 visualisation	accelerated cd47 concert demonstrates diabetogenic displayed drive drives enables encodes idd13 idd5 immunopathogenesis insight insulitis islet locus mechanistic nod paired potency potentiate recapitulates restricted t1d transgene variations
Tagcloud (Difference) ?		acc adenoid aetiology bbc col9a3 constitutes driver drivers foxa1 gpm6b insidious lacks massive mel metastasise metastasises mia myoepithelial neuroblastomaand oestrogen recur ropn1 ropn1b segregated shares signatures silico sox10 visualisation	accelerated cd47 concert demonstrates diabetogenic displayed drive drives enables encodes idd13 idd5 immunopathogenesis insight insulitis islet locus mechanistic nod paired potency potentiate recapitulates restricted t1d transgene variations
Tagcloud (Intersection) ?