RNF139

Description		ring finger protein 139
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Destabilization ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: CDK4
Interacting Genes		7 interacting genes: CFTR COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		11236
HPRD ID		04333
Ensembl ID		ENSG00000170881
Uniprot IDs		Q8WU17
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Eukaryotic Translation Initiation Factor 3 Complex Ubiquitin-dependent Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Protein Ubiquitination ATP Binding Proteolysis Involved In Protein Catabolic Process Translation Initiation Factor Activity Protein Modification Process Nucleotide Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Translational Initiation Enzyme Binding Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Anion Channel Activity Macromolecule Catabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Macrophage Migration Inhibitory Factor Binding Proteasomal Protein Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Monoatomic Anion Transport Translation Reinitiation Multi-eIF Complex Cytosol Positive Regulation Of Enamel Mineralization Exosomal Secretion Transepithelial Water Transport Protein Catabolic Process Viral Translational Termination-reinitiation HULC Complex Cellular Response To Ionomycin Positive Regulation Of Tooth Mineralization DeNEDDylase Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Molecular Adaptor Activity Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transcription Elongation Factor Activity
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