RNF139 and UBE2U

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF139	UBE2U
Description		ring finger protein 139	ubiquitin conjugating enzyme E2 U
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	HULC Complex
	Molecular Function	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Destabilization ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		ER Quality Control Compartment (ERQC)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Severe bacterial meningitis ( 31092817)
Interacting Genes		7 interacting genes: CFTR COPS5 EIF3A UBE2H UBE2U UBE2Z VHL	69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		11236	148581
HPRD ID		04333	14599
Ensembl ID		ENSG00000170881	ENSG00000177414
Uniprot IDs		Q8WU17	A0A0A0MRP4 A0A140VJY9 Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Eukaryotic Translation Initiation Factor 3 Complex Ubiquitin-dependent Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Protein Ubiquitination ATP Binding Proteolysis Involved In Protein Catabolic Process Translation Initiation Factor Activity Protein Modification Process Nucleotide Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Translational Initiation Enzyme Binding Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Anion Channel Activity Macromolecule Catabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Macrophage Migration Inhibitory Factor Binding Proteasomal Protein Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Monoatomic Anion Transport Translation Reinitiation Multi-eIF Complex Cytosol Positive Regulation Of Enamel Mineralization Exosomal Secretion Transepithelial Water Transport Protein Catabolic Process Viral Translational Termination-reinitiation HULC Complex Cellular Response To Ionomycin Positive Regulation Of Tooth Mineralization DeNEDDylase Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Molecular Adaptor Activity Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transcription Elongation Factor Activity	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing
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