CSTA and UCHL5

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		CSTA	UCHL5
Gene Name		cystatin A (stefin A)	ubiquitin carboxyl-terminal hydrolase L5
Image
Gene Ontology Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytosol Ino80 Complex
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Structural Molecule Activity Protein Binding, Bridging	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding
	Biological Process	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Single Organismal Cell-cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Calcium levels ( 20705733)	Cannabis dependence ( 21668797)
Protein-Protein Interactions		12 interactors: CTSB CTSH CTSL DSP EVPL IVL KRT1 LOR PI3 PTN UCHL5 ZDHHC17	96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1
Entrez ID		1475	51377
HPRD ID		01697	10293
Ensembl ID		ENSG00000121552	ENSG00000116750
Uniprot IDs		P01040 Q6IB90	Q9Y5K5
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE	3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Skin Development Keratinocyte Differentiation Epidermal Cell Differentiation Organ Development Keratinization Epithelial Cell Differentiation Tissue Development Epithelium Development Epidermis Development Protein Metabolic Process System Development Multicellular Organismal Development Anatomical Structure Development Developmental Process Cellular Protein Metabolic Process Collagen Catabolic Process Regulation Of Immune Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Endopeptidase Activity Multicellular Organismal Metabolic Process Regulation Of Peptidase Activity Extracellular Matrix Disassembly Ventricular Compact Myocardium Morphogenesis Neuropeptide Catabolic Process Macrophage Apoptotic Process Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Activation Of Innate Immune Response Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hormone Stimulus Bradykinin Catabolic Process Immune Response Regulation Of Immune System Process Protein Catabolic Process Positive Regulation Of Immune Response Tissue Homeostasis Positive Regulation Of Innate Immune Response Myeloid Cell Apoptotic Process Complement Activation, Lectin Pathway	Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process
Tagcloud ?		abcc3 abcc5 amphiregulin areg ccna2 ctsd cycloheximide dissimilar dleu2 efna1 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Difference) ?		abcc3 abcc5 amphiregulin areg ccna2 ctsd cycloheximide dissimilar dleu2 efna1 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Intersection) ?