CSTA and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		CSTA	UCHL5
Description		cystatin A	ubiquitin C-terminal hydrolase L5
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Formation of the cornified envelope	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)	Cannabis dependence ( 21668797)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		1475	51377
HPRD ID		01697	10293
Ensembl ID		ENSG00000121552	ENSG00000116750
Uniprot IDs		P01040	Q5LJA5 Q9Y5K5
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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