CSTA and PI3

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
BioGRID (pull down)

		CSTA	PI3
Description		cystatin A	peptidase inhibitor 3
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis Peptidase Inhibitor Activity
	Biological Process	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion	Copulation Peptide Cross-linking Antibacterial Humoral Response Innate Immune Response
Pathways		Formation of the cornified envelope	Antimicrobial peptides Formation of the cornified envelope
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Malaria ( 31844061)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17	5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN
Entrez ID		1475	5266
HPRD ID		01697	15947
Ensembl ID		ENSG00000121552	ENSG00000124102
Uniprot IDs		P01040	P19957
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7	1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant	Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Protein Metabolic Process Protein Modification Process Cytoskeleton Organization Structural Constituent Of Skin Epidermis Epithelial Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Macromolecule Metabolic Process Developmental Process Elastin Catabolic Process Pancreas Morphogenesis Epidermis Development Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate Filament Peptidase Inhibitor Complex Cellular Response To Progesterone Stimulus Elastin Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Antibacterial Peptide Production Regulation Of Defense Response Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Activation Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Dephosphorylation Osteoclast Development Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Signal Complex Assembly Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Signaling Receptor Activator Activity Cell Differentiation Exocrine Pancreas Development Digestive System Development Regulation Of Antimicrobial Humoral Response Regulation Of Immune Response Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Lamellipodium Morphogenesis Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Positive Regulation Of Integrin Activation Phospholipase Activator Activity
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