CSTA

Description		cystatin A
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)
Novel Interacting Genes		1 novel interacting genes: CD86
Interacting Genes		12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17
Entrez ID		1475
HPRD ID		01697
Ensembl ID		ENSG00000121552
Uniprot IDs		P01040
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant
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