CSTA and CTSH

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (x-ray crystallography, affinity chromatography technology)
HPRD (in vitro)

		CSTA	CTSH
Description		cystatin A	cathepsin H
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex	Outer Dense Fiber Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytosol Axoneme Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Identical Protein Binding Protein-containing Complex Binding Thyroid Hormone Binding
	Biological Process	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Apoptotic Process Immune Response Spermatogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Surfactant Homeostasis Proteolysis Involved In Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Lysosomal Protein Catabolic Process Response To Odorant Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Formation of the cornified envelope	MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation
Drugs			N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases			Type I diabetes mellitus
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)	Aspartate aminotransferase levels ( 33547301) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 24076602 31604244) Narcolepsy ( 23459209) Type 1 diabetes ( 18978792 19430480 25751624 30572963)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17	5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1
Entrez ID		1475	1512
HPRD ID		01697	00288
Ensembl ID		ENSG00000121552	ENSG00000103811
Uniprot IDs		P01040	E9PKT6 P09668
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7	6CZK 6CZS
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant	Response To Testosterone Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Space Peptidase Inhibitor Activity Protease Binding Negative Regulation Of Protein Metabolic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Proteolysis Hydroxyapatite Binding Response To Vitamin K Response To Hydroxyisoflavone Response To Gravity Response To Phenylpropanoid Response To Ketone Regulation Of Testosterone Biosynthetic Process Cellular Response To Zinc Ion Starvation Peptidase Inhibitor Complex Multivesicular Body Lumen Lamellar Body Alveolar Lamellar Body Response To Cycloheximide 5'-3' RNA Exonuclease Activity Response To Alcohol G-quadruplex RNA Binding Response To Macrophage Colony-stimulating Factor G-quadruplex DNA Binding Regulation Of Bone Development 5'-3' Exonuclease Activity Cellular Response To Vitamin D Nuclear MRNA Surveillance Histone MRNA Catabolic Process Regulation Of Proteolysis RRNA Catabolic Process Type B Pancreatic Cell Proliferation Peptide Cross-linking Positive Regulation Of Neurotransmitter Secretion Regulation Of Ketone Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Clathrin-coated Endocytic Vesicle Dendrite Histone MRNA Metabolic Process Response To Vitamin D Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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