CSTA and LORICRIN

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
BioGRID (pull down)

		CSTA	LORICRIN
Description		cystatin A	loricrin cornified envelope precursor protein
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Keratinization
Pathways		Formation of the cornified envelope	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases			Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17	8 interacting genes: CSTA EVPL IVL KRT1 PI3 SLC26A4-AS1 SPRR3 VIM
Entrez ID		1475	4014
HPRD ID		01697	01070
Ensembl ID		ENSG00000121552	ENSG00000203782
Uniprot IDs		P01040	P23490
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant	Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Epidermis Development Intermediate Filament Endopeptidase Inhibitor Activity Intermediate Filament Cytoskeleton Protein Modification Process Structural Constituent Of Skin Epidermis Wound Healing Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Organization Copulation Extracellular Exosome Peptidase Inhibitor Activity Peptidase Inhibitor Complex Cell Differentiation Cytosol Regulation Of Antibacterial Peptide Production Keratin Filament Binding Structural Molecule Activity Tissue Development Lens Fiber Cell Development Response To Wounding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Cellular Developmental Process Protein Metabolic Process Regulation Of Antimicrobial Humoral Response Complement Activation, Lectin Pathway Humoral Immune Response Protein Heterotetramerization
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