SESN2

Description		sestrin 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Nucleotide-activated Protein Kinase Complex TORC2 Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Peroxidase Activity GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity PH Domain Binding Protein-containing Complex Binding L-leucine Binding Protein Sequestering Activity
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Mitochondrion Organization Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis D-glucose Import Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Triglyceride Homeostasis Protein K63-linked Ubiquitination Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Protein K6-linked Ubiquitination Cellular Oxidant Detoxification Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation
Pathways		TP53 Regulates Metabolic Genes Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: CRYAA MDM2 PRDX1 RNF167 RNF186 STAMBPL1
Entrez ID		83667
HPRD ID		06378
Ensembl ID		ENSG00000130766
Uniprot IDs		P58004
PDB IDs		5CUF 5DJ4 5T0N 6N0M
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To Leucine Starvation Protein K29-linked Ubiquitination Response To Reactive Oxygen Species Protein Ubiquitination Response To Stress Protein Modification By Small Protein Conjugation Protein K6-linked Ubiquitination Cellular Response To Nutrient Levels Ubiquitin-protein Transferase Activity Post-translational Protein Modification Response To Oxidative Stress Ubiquitin Protein Ligase Activity Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Protein Autoubiquitination Protein K63-linked Ubiquitination Proteolysis Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of TOR Signaling Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Response To Hydrogen Peroxide Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Stress Protein Modification Process Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Proteolysis Involved In Protein Catabolic Process Regulation Of TOR Signaling Response To UV NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Intracellular Signal Transduction Cellular Response To UV-C Thioredoxin-dependent Peroxiredoxin Activity Cellular Response To Starvation Metal Ion Binding Receptor Serine/threonine Kinase Binding Catabolic Process Peroxiredoxin Activity
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