SESN2 and PRDX1

Number of citations of the paper that reports this interaction (PubMedID 15105503)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SESN2	PRDX1
Description		sestrin 2	peroxiredoxin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Nucleotide-activated Protein Kinase Complex TORC2 Complex Atg1/ULK1 Kinase Complex	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	Peroxidase Activity GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity PH Domain Binding Protein-containing Complex Binding L-leucine Binding Protein Sequestering Activity	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Mitochondrion Organization Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis D-glucose Import Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Triglyceride Homeostasis Protein K63-linked Ubiquitination Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Protein K6-linked Ubiquitination Cellular Oxidant Detoxification Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		TP53 Regulates Metabolic Genes Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		6 interacting genes: CRYAA MDM2 PRDX1 RNF167 RNF186 STAMBPL1	31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		83667	5052
HPRD ID		06378	01458
Ensembl ID		ENSG00000130766	ENSG00000117450
Uniprot IDs		P58004	A0A384NPQ2 Q06830
PDB IDs		5CUF 5DJ4 5T0N 6N0M	2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To Leucine Starvation Protein K29-linked Ubiquitination Response To Reactive Oxygen Species Protein Ubiquitination Response To Stress Protein Modification By Small Protein Conjugation Protein K6-linked Ubiquitination Cellular Response To Nutrient Levels Ubiquitin-protein Transferase Activity Post-translational Protein Modification Response To Oxidative Stress Ubiquitin Protein Ligase Activity Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Protein Autoubiquitination Protein K63-linked Ubiquitination Proteolysis Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of TOR Signaling Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Response To Hydrogen Peroxide Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Stress Protein Modification Process Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Proteolysis Involved In Protein Catabolic Process Regulation Of TOR Signaling Response To UV NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Intracellular Signal Transduction Cellular Response To UV-C Thioredoxin-dependent Peroxiredoxin Activity Cellular Response To Starvation Metal Ion Binding Receptor Serine/threonine Kinase Binding Catabolic Process Peroxiredoxin Activity	Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process
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