SLC20A1 and RAPGEF1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SLC20A1	RAPGEF1
Name		solute carrier family 20 member 1	Rap guanine nucleotide exchange factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Phosphate Transmembrane Transporter Activity High-affinity Phosphate:sodium Symporter Activity Sodium:phosphate Symporter Activity Symporter Activity Signaling Receptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Cell Population Proliferation Biomineral Tissue Development Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways		Sodium-coupled phosphate cotransporters	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
GWAS		No GWAS studies recorded	Cerebrospinal fluid α-synuclein levels ( 29959729 ) Cutaneous malignant melanoma ( 32341527 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Kidney volume ( 34128465 ) Nevus count or cutaneous melanoma ( 32341527 ) Optic disc size ( 31809533 )
Novel Interactors		1 novel interactors: IL4R	1 novel interactors: PDGFRA
Interacting Genes		4 interacting genes: BCL10 CRYAA MAPK6 RAPGEF1	19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		6574	2889
HPRD ID		08846	02627
Ensembl ID		ENSG00000144136	ENSG00000107263
Uniprot IDs		A7LNJ1 Q8WUM9	A0A1S5UYZ7 A0A804HL87 Q13905
PDB IDs		Not available	5L23
GO Terms Enriched among Interactors		Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of T-helper 1 Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Interleukin-4 Receptor Activity Septin Cytoskeleton Polkadots Positive Regulation Of Lymphotoxin A Production Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Production Of Molecular Mediator Of Immune Response CBM Complex Positive Regulation Of Mast Cell Cytokine Production Tubulin Complex Assembly Response To UV-A Lens Fiber Cell Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Effector Process Positive Regulation Of Cell-cell Adhesion T-helper 2 Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 1 Type Immune Response Interleukin-4-mediated Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T-helper 1 Cell Differentiation Immune Effector Process Positive Regulation Of T-helper 2 Cell Differentiation Regulation Of T Cell Activation Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion MAP Kinase Activity Negative Regulation Of B Cell Apoptotic Process Kinase Activator Activity Antifungal Innate Immune Response CARD Domain Binding B Cell Apoptotic Process Protein Kinase B Binding General Transcription Initiation Factor Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Small GTPase-mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament-based Process Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway GDP Binding Regulation Of Protein Localization To Membrane Regulation Of Cell Migration Response To Growth Factor Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Locomotion Positive Regulation Of Signaling Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Rap Protein Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Focal Adhesion Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Lymphocyte Migration Cytosol Cell Motility GTPase Activity