SLC20A1 and BCL10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SLC20A1	BCL10
Description		solute carrier family 20 member 1	BCL10 immune signaling adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphate Transmembrane Transporter Activity High-affinity Phosphate:sodium Symporter Activity Sodium:phosphate Symporter Activity Symporter Activity Signaling Receptor Activity	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Cell Population Proliferation Biomineral Tissue Development Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Sodium-coupled phosphate cotransporters	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		4 interacting genes: BCL10 CRYAA MAPK6 RAPGEF1	45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		6574	8915
HPRD ID		08846	04625
Ensembl ID		ENSG00000144136	ENSG00000142867
Uniprot IDs		A7LNJ1 Q8WUM9	A0A087WWW9 A2TDT2 O95999
PDB IDs			2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of T-helper 1 Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Interleukin-4 Receptor Activity Septin Cytoskeleton Polkadots Positive Regulation Of Lymphotoxin A Production Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Production Of Molecular Mediator Of Immune Response CBM Complex Positive Regulation Of Mast Cell Cytokine Production Tubulin Complex Assembly Response To UV-A Lens Fiber Cell Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Effector Process Positive Regulation Of Cell-cell Adhesion T-helper 2 Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 1 Type Immune Response Interleukin-4-mediated Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T-helper 1 Cell Differentiation Immune Effector Process Positive Regulation Of T-helper 2 Cell Differentiation Regulation Of T Cell Activation Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion MAP Kinase Activity Negative Regulation Of B Cell Apoptotic Process Kinase Activator Activity Antifungal Innate Immune Response CARD Domain Binding B Cell Apoptotic Process Protein Kinase B Binding General Transcription Initiation Factor Binding	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process
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