CDC40 and DHX38

Number of citations of the paper that reports this interaction (PMID 9524131)
29

Data Source:
HPRD (in vitro)

		CDC40	DHX38
Gene Name		cell division cycle 40	DEAH (Asp-Glu-Ala-His) box polypeptide 38
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		3 interactors: DHX38 SMAD2 SMURF1	6 interactors: CDC40 CSNK2A1 MFAP1 PPP4C TERF2IP U2AF1
Entrez ID		51362	9785
HPRD ID		05721	05720
Ensembl ID		ENSG00000168438	ENSG00000140829
Uniprot IDs		O60508	Q92620
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nuclear Export Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Nucleocytoplasmic Transport Nuclear Transport Establishment Of Localization In Cell Positive Regulation Of Mesoderm Development Primary MiRNA Processing Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Cellular Localization SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis RNA Processing Cellular Response To Growth Factor Stimulus Response To Growth Factor Nodal Signaling Pathway Protein Localization To Cell Surface Receptor Catabolic Process Cytoplasmic Transport Production Of MiRNAs Involved In Gene Silencing By MiRNA Embryonic Foregut Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification Ectoderm Development Pericardium Development Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Signal Transduction Involved In Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of BMP Signaling Pathway	Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Termination Of RNA Polymerase II Transcription Regulation Of DNA Repair MRNA Export From Nucleus Regulation Of DNA Recombination DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere RNA 3'-end Processing Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus RNA Transport RNA Localization Regulation Of Chromosome Organization Transcription, DNA-templated Protection From Non-homologous End Joining At Telomere RNA Biosynthetic Process MRNA Splicing, Via Spliceosome Telomere Capping Protein Localization To Chromosome, Telomeric Region RNA Splicing, Via Transesterification Reactions Nucleocytoplasmic Transport Nuclear Transport Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance RNA Splicing RNA Metabolic Process MRNA Processing Regulation Of Telomere Maintenance Gene Expression RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening RNA Processing Mitotic Spindle Checkpoint NIK/NF-kappaB Signaling Negative Regulation Of Chromosome Segregation Cytoplasmic Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition
Tagcloud ?		18s actb ap3d1 bestkeeper c2c12 csnk2a2 dystrophic dystrophin exceptionally fbxo38 fbxw2 gapdh genorm h2k2b4 h2ksf1 htatsf1 informative mef2c myoblasts myod myogenesis myogenic myogenin normalization normalizing normfinder packages pak1ip1 zfp91
Tagcloud (Difference) ?		18s actb ap3d1 bestkeeper c2c12 csnk2a2 dystrophic dystrophin exceptionally fbxo38 fbxw2 gapdh genorm h2k2b4 h2ksf1 htatsf1 informative mef2c myoblasts myod myogenesis myogenic myogenin normalization normalizing normfinder packages pak1ip1 zfp91
Tagcloud (Intersection) ?