CRYGC and TRIM7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRYGC	TRIM7
Description		crystallin gamma C	tripartite motif containing 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Golgi Apparatus
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lens Development In Camera-type Eye Visual Perception	Protein Ubiquitination Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057)
Interacting Genes		8 interacting genes: CRYAA CRYAB CRYBB2 CRYGD HSPB1 HSPB2 MIP TRIM7	30 interacting genes: AQP1 ATG7 BCAM CDK13 CFL2 CRYGC CTNNAL1 DES GTF2A2 GYG1 IRAK4 MAD2L2 NAA35 NABP1 OTUD6A RAB2A RIN1 RNASE1 RNF187 RSPH14 SIAH1 SRC TP53I13 TRMT10A UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N UBE2W
Entrez ID		1420	81786
HPRD ID		00435	11648
Ensembl ID		ENSG00000163254	ENSG00000146054
Uniprot IDs		A0A0X8GLL6 P07315	Q9C029
PDB IDs		2NBR	6UMA 6UMB 7OVX 7OW2 7W0Q 7W0S 7W0T 7X6Y 7X6Z 7X70 7Y3A 7Y3B 7Y3C 8A5L 8A5M 8A8X 8R5B 8R5C 8R5D 9HIN
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Protein Refolding Response To Heat Unfolded Protein Binding Response To Temperature Stimulus Visual Perception Sensory Perception Of Light Stimulus Protein Folding Camera-type Eye Development Tubulin Complex Assembly Contractile Muscle Fiber Eye Development Sensory Perception Response To Reactive Oxygen Species Apoptotic Process Involved In Morphogenesis Sensory Organ Development Structural Molecule Activity Apoptotic Process Involved In Development System Process Negative Regulation Of Intracellular Transport Negative Regulation Of Apoptotic Process Homotypic Cell-cell Adhesion Nervous System Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Protein Kinase C Signaling Response To Oxidative Stress Response To Unfolded Protein Response To Stress Response To Hydrogen Peroxide Protein Kinase C Inhibitor Activity Z Disc Muscle Structure Development Somatic Muscle Development Regulation Of Protein Kinase C Signaling Regulation Of Apoptotic Process Gap Junction-mediated Intercellular Transport Regulation Of Programmed Cell Death Lens Fiber Cell Morphogenesis Cardiac Myofibril Maintenance Of Lens Transparency Actin Filament Bundle Anterograde Axonal Protein Transport Intercellular Transport Microtubule-based Process Protein Stabilization Identical Protein Binding Cell Adhesion Mediator Activity Response To UV-A Regulation Of Intracellular Transport	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein Ubiquitination TOR Signaling Proteasomal Protein Catabolic Process Negative Regulation Of TOR Signaling Proteolysis Regulation Of TORC1 Signaling Macromolecule Catabolic Process Protein Modification Process Cytosol Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of TOR Signaling Catabolic Process Protein Autoubiquitination Nucleus Ubiquitin Protein Ligase Activity Extracellular Exosome ATP Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Polyubiquitination Nucleotide Binding Intracellular Signal Transduction Protein Binding Endolysosomal Toll-like Receptor Signaling Pathway Macromolecule Metabolic Process Ephrin Receptor Binding Regulation Of Protein Polyubiquitination Ficolin-1-rich Granule Lumen Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Supramolecular Fiber Organization Defense Response To Virus Response To Nutrient Levels Postreplication Repair
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