CTCFL and H2AC20

Number of citations of the paper that reports this interaction (PubMedID 17048991)
46

Data Source:
BioGRID (far western blotting, pull down)

		CTCFL	H2AC20
Description		CCCTC-binding factor like	H2A clustered histone 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Genomic Imprinting	Heterochromatin Formation
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obesity-related traits ( 23251661) Prudent dietary pattern ( 28644415) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Type 2 diabetes ( 23300278)
Interacting Genes		10 interacting genes: AURKA BAG6 BRCA1 H1-1 H2AC20 H3C1 PRMT7 SP1 TBP ZDHHC17	72 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CEBPA CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBE2H UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8
Entrez ID		140690	8338
HPRD ID		09512	09107
Ensembl ID		ENSG00000124092	ENSG00000184260
Uniprot IDs		A6XGM0 A6XGM9 Q8NI51 V9GY73 V9GYX4	Q16777
PDB IDs			6Y5E 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8SPS 8SPU 8SYP
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Euchromatin Pronucleus Epigenetic Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Nucleoplasm Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Transcription Cis-regulatory Region Binding Centrosome Cycle Regulation Of Centrosome Cycle DNA Binding Chromosome Regulation Of Metabolic Process Male Germ Cell Nucleus Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Perforant Pathway To Dendrate Granule Cell Synapse Ubiquitin Protein Ligase Binding Histone H2AK127 Ubiquitin Ligase Activity Nucleus Microtubule Organizing Center Organization Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Programmed Cell Death Cellular Component Assembly Chromosome Organization Response To Wortmannin Protein Heterodimerization Activity Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protein Modification Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Oocyte Maturation BAT3 Complex Protein-arginine Omega-N Symmetric Methyltransferase Activity Nucleosome Assembly BRCA1-B Complex Regulation Of Cell Cycle G2/M Phase Transition Male Gamete Generation Spermatogenesis Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Positive Regulation Of Proteasomal Protein Catabolic Process Histone H3S10 Kinase Activity TFIIB-class Transcription Factor Binding	Chromatin Organization Chromatin Remodeling Nucleus Histone Binding Nucleoplasm Epigenetic Regulation Of Gene Expression Chromatin Binding Chromosome Protein Modification Process Macromolecule Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Gene Expression Histone H4 Acetyltransferase Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone H2A Deubiquitinase Activity Protein Deubiquitination Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity DNA Damage Response Protein Modification By Small Protein Removal Negative Regulation Of Biosynthetic Process Transferase Activity Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cysteine-type Peptidase Activity Protein-containing Complex Positive Regulation Of DNA-templated Transcription
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