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CREB1 and KCNIP3
Number of citations of the paper that reports this interaction (PMID
12198160
)
18
Data Source:
HPRD
(in vivo, in vitro)
CREB1
KCNIP3
Gene Name
cAMP responsive element binding protein 1
Kv channel interacting protein 3, calsenilin
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nuclear Euchromatin
ATF1-ATF4 Transcription Factor Complex
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Dendrite
Protein-DNA Complex
Axon Terminus
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Transcription Cofactor Activity
Protein Binding
Enzyme Binding
CAMP Response Element Binding
DNA Binding
Transcription Corepressor Activity
Voltage-gated Ion Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein C-terminus Binding
Potassium Channel Regulator Activity
Sequence-specific DNA Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Biological Process
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription From RNA Polymerase II Promoter
Protein Phosphorylation
Organelle Organization
Mitochondrion Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Notch Signaling Pathway
Synaptic Transmission
Axon Guidance
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Viral Process
Pituitary Gland Development
Secretory Granule Organization
Response To Glucagon
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Innate Immune Response
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Protein Stabilization
Stress-activated MAPK Cascade
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Sensory Perception Of Pain
Regulation Of Ion Transmembrane Transport
Regulation Of Neuron Apoptotic Process
Behavioral Response To Pain
Potassium Ion Transmembrane Transport
Pathways
Signaling by the B Cell Receptor (BCR)
Ca-dependent events
Signaling by GPCR
CaM pathway
Phospholipase C-mediated cascade
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
CREB phosphorylation through the activation of Ras
PLCG1 events in ERBB2 signaling
NOTCH2 intracellular domain regulates transcription
Signaling by SCF-KIT
Toll Like Receptor TLR1:TLR2 Cascade
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
Signaling by NOTCH2
PI3K/AKT activation
Toll Like Receptor 5 (TLR5) Cascade
PI-3K cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by PDGF
Calmodulin induced events
CaMK IV-mediated phosphorylation of CREB
DAP12 interactions
PKA-mediated phosphorylation of CREB
GAB1 signalosome
Signaling by NOTCH
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
CREB phosphorylation through the activation of Adenylate Cyclase
EGFR interacts with phospholipase C-gamma
CaMK IV-mediated phosphorylation of CREB
Toll Like Receptor 2 (TLR2) Cascade
Signaling by ERBB2
PKA-mediated phosphorylation of CREB
Signaling by EGFR
CREB phosphorylation through the activation of CaMKK
AKT phosphorylates targets in the nucleus
Calmodulin induced events
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Downstream signal transduction
CREB phosphorylation through the activation of CaMKII
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Transcriptional activation of mitochondrial biogenesis
Transmission across Chemical Synapses
Adaptive Immune System
Organelle biogenesis and maintenance
CREB phosphorylation
Axon guidance
PIP3 activates AKT signaling
Toll Like Receptor 7/8 (TLR7/8) Cascade
CREB phosphorylation
DAG and IP3 signaling
Toll Like Receptor TLR6:TLR2 Cascade
CaM pathway
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
PI3K events in ERBB2 signaling
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Downstream signaling of activated FGFR
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
NCAM signaling for neurite out-growth
Post NMDA receptor activation events
Innate Immune System
Signalling by NGF
PLC beta mediated events
MAP kinase activation in TLR cascade
Signaling by Ligand-Responsive EGFR Variants in Cancer
G-protein mediated events
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
Mitochondrial biogenesis
Signaling by FGFR
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
PLC-gamma1 signalling
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Adenosine monophosphate
Naloxone
Diseases
GWAS
Protein-Protein Interactions
75 interactors:
ABL1
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
C14orf1
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
DYRK1A
EDF1
EP300
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
MYC
NR3C1
PDX1
PIAS1
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
17 interactors:
ADRBK1
CALM2
CASP3
CD177
CLN3
CREB1
CREM
GRK6
IGF1R
IGLV3-25
IL6ST
MAVS
PCBD2
PPP3CA
PSEN1
PSEN2
TARBP2
Entrez ID
1385
30818
HPRD ID
00442
05232
Ensembl ID
ENSG00000118260
ENSG00000115041
Uniprot IDs
P16220
Q53X93
Q5U0J5
Q9Y2W7
PDB IDs
2LXT
2E6W
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Gene Expression
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Peptidyl-serine Phosphorylation
Negative Regulation Of Gene Expression
Regulation Of Cellular Process
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Response To Organic Substance
Cellular Response To Stress
Cellular Response To Organic Substance
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromosome Organization
Chromatin Modification
Chromatin Organization
Response To Stress
Regulation Of Signaling
Peptidyl-amino Acid Modification
Regulation Of Cellular Response To Heat
Organelle Organization
Cell Differentiation
Transcription From RNA Polymerase II Promoter
Amyloid Precursor Protein Catabolic Process
Regulation Of Immune System Process
Negative Regulation Of Protein Phosphorylation
Cellular Response To Organic Substance
Response To Organic Substance
Positive Regulation Of Metabolic Process
Negative Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Regulation Of Protein Phosphorylation
Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Immune Response
Regulation Of Phosphorylation
Regulation Of Immune Response
Negative Regulation Of Protein Metabolic Process
Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Regulation Of Phosphorus Metabolic Process
Signaling
Negative Regulation Of Cellular Metabolic Process
Cell Communication
Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Signaling
Regulation Of Protein Kinase Activity
Activation Of Phospholipase C Activity
Negative Regulation Of Signaling
Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Phospholipase C Activity
Regulation Of Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Protein Kinase Activity
Response To Stress
Negative Regulation Of Kinase Activity
Protein Processing
Negative Regulation Of Apoptotic Process
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Programmed Cell Death
Learning Or Memory
Tagcloud
?
aao
acting
allelic
chemokine
citrate
emerged
enrichment
exceeded
fact
fdr
fdraao
fdrmsss
gwas
hubs
influencing
italian
leukocyte
msss
network
networks
nominally
ppms
sclerosis
severity
snps
tca
trait
traits
transendothelial
Tagcloud (Difference)
?
aao
acting
allelic
chemokine
citrate
emerged
enrichment
exceeded
fact
fdr
fdraao
fdrmsss
gwas
hubs
influencing
italian
leukocyte
msss
network
networks
nominally
ppms
sclerosis
severity
snps
tca
trait
traits
transendothelial
Tagcloud (Intersection)
?