CREB1 and HIVEP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CREB1	HIVEP1
Description		cAMP responsive element binding protein 1	HIVEP zinc finger 1
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Centrosome Cytosol Axon Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Response To Purine-containing Compound Response To Activity Pituitary Gland Development Cell Differentiation Osteoclast Differentiation Mammary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonate Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Response To Erythropoietin Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Response To Cocaine MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Hormone Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Rhythmic Process Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Epithelium Development Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Fatty Acid Cellular Response To Transforming Growth Factor Beta Stimulus CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Response To L-glutamate Response To Dehydroepiandrosterone Positive Regulation Of Membrane Depolarization Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Response To Hypobaric Hypoxia Regulation Of Testosterone Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs		Adenosine phosphate Naloxone
Diseases
GWAS		Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) Food antigen IgG levels ( 24962563) Mean corpuscular hemoglobin ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 22488850) Asthma ( 32296059) Body mass index ( 25673413 28892062 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Takayasu arteritis ( 25604533)
Interacting Genes		86 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR BRD10 CAMK2A CCDC6 CDK1 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 CSNK1D CSNK2A1 CSNK2B DNMT3L DYRK1A EDF1 ERG28 ETS1 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 PTEN RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	72 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BANP BHLHE40 BNIP3 BRCA1 CACNA1A CCNK CDC37 CLK1 CREB1 CREBBP DNAJA1 ELOA EMG1 FXR1 FXR2 GAA GSDMB HPD HSPA1A IGFN1 IMMT KDF1 MAGED1 MAPK14 MAPK8 MIEN1 MTMR3 NINJ1 NLGN3 NRF1 NUCB1 OGT OTX1 PLEKHB2 POGZ POU2F1 POU6F2 PRKAR1A PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAB1A RBM47 RBPMS RIDA RNF186 ROR2 SDCBP SERTAD1 SH3KBP1 SMAD3 SNX4 SOCS3 SOX10 SP4 SRPK2 STAT3 TENT5B TMEM176A VCF2 VEZF1 ZC3H10 ZFHX3
Entrez ID		1385	3096
HPRD ID		00442	01925
Ensembl ID		ENSG00000118260	ENSG00000095951
Uniprot IDs		B7Z5C6 P16220 Q53X93 Q5U0J5	A0A0D9SFF3 A0AAQ5BHS1 H7BYU7 P15822
PDB IDs		2LXT 5ZK1 5ZKO 7TBH	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Protein Kinase Activity PML Body Kinase Activity Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation ATP Binding Transferase Activity Chromatin Remodeling Phosphorylation Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of CREB Transcription Factor Activity DNA-binding Transcription Factor Activity Chromatin Organization Sequence-specific DNA Binding Nucleic Acid Metabolic Process Intracellular Signal Transduction	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Stability Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Chromatin Regulation Of Developmental Process Regulation Of Biological Quality Transcription By RNA Polymerase II Pyroptotic Inflammatory Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Enzyme Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Regulation Of Multicellular Organismal Process Rhythmic Process DNA-binding Transcription Factor Activity POZ Domain Binding Regulation Of Circadian Rhythm Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Splicing MRF Binding C3HC4-type RING Finger Domain Binding Regulation Of MiRNA-mediated Gene Silencing
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