CREB1 and PDX1

Number of citations of the paper that reports this interaction (PMID 7505393)
75

Data Source:
HPRD (in vivo)

		CREB1	PDX1
Gene Name		cAMP responsive element binding protein 1	pancreatic and duodenal homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin ATF1-ATF4 Transcription Factor Complex	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Enzyme Binding CAMP Response Element Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Protein Heterodimerization Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Protein Phosphorylation Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Notch Signaling Pathway Synaptic Transmission Axon Guidance Lactation Memory Circadian Rhythm Regulation Of Cell Size Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Transcription By Competitive Promoter Binding Viral Process Pituitary Gland Development Secretory Granule Organization Response To Glucagon Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Drug Innate Immune Response Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization Stress-activated MAPK Cascade Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Endocrine Pancreas Development Organ Regeneration Positive Regulation Of Insulin Secretion Response To Vitamin Response To Cytokine Response To Nicotine Response To Drug Glucose Homeostasis Response To Leucine Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling NOTCH2 intracellular domain regulates transcription Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Signaling by NOTCH2 PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions PKA-mediated phosphorylation of CREB GAB1 signalosome Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling Opioid Signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR CREB phosphorylation through the activation of CaMKK AKT phosphorylates targets in the nucleus Calmodulin induced events Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction CREB phosphorylation through the activation of CaMKII Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance CREB phosphorylation Axon guidance PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation DAG and IP3 signaling Toll Like Receptor TLR6:TLR2 Cascade CaM pathway Activated TLR4 signalling MyD88 cascade initiated on plasma membrane PI3K events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Post NMDA receptor activation events Innate Immune System Signalling by NGF PLC beta mediated events MAP kinase activation in TLR cascade Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis Signaling by FGFR Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade PLC-gamma1 signalling MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in beta cells
Drugs		Adenosine monophosphate Naloxone
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Fasting glucose-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		75 interactors: ABL1 AKT1 ATF1 ATF6 ATF7IP ATM ATR C14orf1 CAMK2A CCDC6 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 DYRK1A EDF1 EP300 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 MYC NR3C1 PDX1 PIAS1 POGZ POU2F1 PPP1CA PRKACA PRKG1 RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	13 interactors: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6
Entrez ID		1385	3651
HPRD ID		00442	02843
Ensembl ID		ENSG00000118260	ENSG00000139515
Uniprot IDs		P16220 Q53X93 Q5U0J5	P52945
PDB IDs		2LXT
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Peptidyl-serine Phosphorylation Negative Regulation Of Gene Expression Regulation Of Cellular Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance Cellular Response To Stress Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Chromatin Organization Response To Stress Regulation Of Signaling Peptidyl-amino Acid Modification Regulation Of Cellular Response To Heat Organelle Organization Cell Differentiation Transcription From RNA Polymerase II Promoter	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Double-strand Break Repair Via Nonhomologous End Joining Organ Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Hyperosmotic Salinity Response Positive Regulation Of Gene Expression V(D)J Recombination Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Head Development Cellular Response To X-ray Endocrine Pancreas Development Immunoglobulin V(D)J Recombination System Development DNA Recombination Central Nervous System Development Transcription, DNA-templated Regulation Of Cell Differentiation Establishment Of Integrated Proviral Latency Anterior/posterior Pattern Specification RNA Biosynthetic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Telomere Maintenance Positive Regulation Of Type I Interferon Production B Cell Lineage Commitment Establishment Of Viral Latency Positive Regulation Of Cellular Metabolic Process Cellular Response To Salt Stress Multicellular Organismal Development Pancreas Development Anatomical Structure Development Immune System Development Regulation Of Neurogenesis Regulation Of Type I Interferon Production Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Regulation Of Protein Stability Immune System Process Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Ionizing Radiation Developmental Process Double-strand Break Repair Transcription From RNA Polymerase II Promoter Hyperosmotic Response
Tagcloud ?		aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial	ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors
Tagcloud (Difference) ?		aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial	ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors
Tagcloud (Intersection) ?